How does exercise ameliorate programming of metabolic dysfunction in offspring of obese mothers?

肥胖是一种世界性疾病，反映了我们的环境（饮食，体育活动）和基因之间的相互作用。我们知道母亲的不健康饮食会使后代容易患糖尿病，运动可以改善这一点，但对潜在的机制知之甚少。在这里，我们将研究运动如何使肥胖母亲的后代受益，并测试一种模拟运动效果的药物。这项拟议的研究将为减少肥胖流行病的方法提供见解。

Obesity is a worldwide disease, reflecting an interaction between our environment (diet, physical activity) and genes. We know that a mother's unhealthy diet can predispose offspring to diabetes, and exercise can improve this, but the underlying mechanisms are poorly understood. Here we will examine how exercise can benefit offspring of obese mothers, and test a drug that mimics the effects of exercise. The proposed research will provide insight into ways of reducing the obesity epidemic.