The relationship between common infections, education, and neurodegeneration and cognitive decline.

2019冠状病毒病大流行让我们更加意识到病毒对健康构成的威胁。普通感染，因为它们的普遍性和潜伏性和惰性，通常被认为是没有威胁的。然而，它们可能在以后的生活中产生长期的有害影响;它们在体内持续存在，并且随着免疫能力的降低，在老年时可能变得更具毒性。越来越多的证据表明，常见感染在神经退行性疾病和认知能力下降中具有潜在作用，尽管还不足以支持因果关系。此外，证据的基本机制和遗传和社会因素在这些关系中的作用是稀缺的。我的项目将试图通过评估常见感染与神经变性的关系来填补这些研究空白，特别是与AD，认知能力下降以及炎症，教育和遗传在这些协会中的作用。

The Covid-19 pandemic has made us more aware of the threats posed by viruses to health. Common infections, because of their ubiquity and their being latent and indolent, are popularly perceived as non-threatening. However, they could have long-term detrimental effects later in life; they persist in the body and could become more virulent at older ages with decreasing immunocompetence. Increasing evidence suggests a potential role of common infections in neurodegenerative disorders and cognitive decline although it is not robust enough to support a causal association. Also, evidence on the underlying mechanisms and on the role of genetic and social factors in these relationships are scarce. My project will try to fill these research gaps by assessing the relationship of common infections with neurodegeneration, particularly in relation to AD, and cognitive decline and the role of inflammation, education, and genetics in these associations.