Thermo Finnigan LCQdecaXP+ Ion Trap Mass Spectrometer

描述（由申请人提供）：我们正在申请资助Thermo Finnigan LCQdecaXP+离子阱质谱仪。多蛋白质复合物的表征已经成为阐明蛋白质/基因功能和理解正常细胞功能以及病理状况（如癌症或糖尿病）如何由这些多蛋白质复合物控制的最有力的方法之一。这种类型的分析为理解基因功能提供了重要的基础，并已成为冷泉港实验室研究的关键组成部分。近年来，质谱法已取代其他技术用于蛋白质鉴定和表征。这在很大程度上是由于质谱法提供的增强的灵敏度、通过量和灵活性。冷泉港实验室癌症中心的蛋白质化学共享资源越来越依赖质谱分析，并正在申请资助Thermo Finnigan LCQdeca XP+质谱仪。LCQdeca XP+是最先进的离子阱质谱仪，以其灵敏度和分析能力而闻名。新的仪器将提高敏感性，可靠性，并通过把这个关键的应用程序，并将有一个重大的影响，共享用户的这笔赠款和更大的冷泉港社区。该仪器将被纳入现有的基于质谱的蛋白质化学共享资源，因此将被整合到现有的组织中，该组织将监督新仪器的管理，操作和维护。

DESCRIPTION (provided by applicant): We are requesting funding for a Thermo Finnigan LCQdecaXP+ ion trap mass spectrometer. Characterization of multi-protein complexes has become one of the most powerful methods for elucidating protein/gene function and for understanding how normal cellular functions, as well as, pathological conditions, such as cancer or diabetes, are controlled by these multi-protein complexes. This type of analysis provides an important foundation for understanding gene function and has become a critical component of research at Cold Spring Harbor Laboratory. In recent years, mass spectrometry has superceded other techniques for protein identification and characterization. This is largely due to the enhanced sensitivity, through put and flexibility provided by mass spectrometry. The Protein Chemistry Shared Resource in the Cold Spring Harbor Laboratory Cancer Center has become increasingly reliant on mass spectrometry and is requesting funding for a Thermo Finnigan LCQdeca XP+ mass spectrometer. The LCQdeca XP+ is a state of the art ion trap mass spectrometer, which is renowned for its sensitivity and analytical capabilities. The new instrumentation will enhance the sensitivity, reliability, and through put of this critical application and will have a major impact on the shared users of this grant and the larger Cold Spring Harbor community. This instrument will be incorporated into an existing mass spectrometry based protein chemistry shared resource, and will therefore be integrated into an existing organization that will oversee the management, operation, and maintenance of the new instrument.