Enzyme Responsive Materials (ERM) for personalised drug delivery

本项目采用酶响应药物释放的概念，合成和设计具有可调药物释放曲线的材料，能够在腹膜腔中提供持久的药物释放。该项目将制备各种酶响应连接体，并将其掺入水凝胶材料中，以研究和调节抗癌药物的释放。这些材料的性能将在体内进行评估，以确定适用于长期药物递送的材料。在手术切除卵巢癌中的肿瘤细胞后，在腹膜腔中长期持续释放药物以杀死肿瘤切除后的残留癌细胞是特别具有挑战性的。这是一个未满足的临床需求，如果得到解决，可能会提高患者的生存率。

This project employs the concept of enzyme responsive drug release to synthesise and design materials with tuneable drug release profiles able to provide long lasting drug release in the peritoneal cavity. The project will prepare a variety of enzyme responsive linkers and incorporate them into hydrogel materials to study and tune the release of anticancer drugs. The performance of these materials will be assessed in vivo to identify materials suitable for long lasting drug delivery. Long lasting drug release to kill residual cancer cells after tumour resection is particularly challenging in the peritoneal cavity after surgical removal of tumour cells in ovarian cancer. This is an unmet clinical need which, if addressed, could lead to improved patient survival rates.