Core E: Research to Practice Core

所提出的研究为开发新的、更有效的烟草处理策略带来了巨大的希望。为了实现这一潜力，我们必须识别和解决在将这项研究转化为临床实践中可能出现的潜在障碍。我们认为，与科学一起解决这些问题至关重要，从而提高产生的新知识应用于临床的可能性，并为减轻吸烟对国家-S健康的负担做出贡献。 因此，该核心将预测与翻译相关的问题，开始一些有针对性的调查，以解决这些问题和关切，并以有效的方式向关键政策制定者和其他利益相关者传达TTURC研究的潜在临床价值。我们的具体目标是： 1)确定与将TTURC研究(用于3项人体研究)转化为改善烟草依赖治疗有关的关键伦理、实践、经济和政策问题并确定优先事项。 2)通过政策分析(3-4篇委托发表的论文)和开始处理这些新出现的政策和伦理问题的试点研究，落实这一研究议程的部分内容。这些试点研究由TTURC发展研究计划支持，将为未来跨学科的R01应用生成初步数据。 3)为3项人类研究制定战略传播计划和适当的传播工具(问题和政策简报、政策会议)，以便接触到其他科学家、决策者、媒体和公众。 研究实践核心是TTURC和宾夕法尼亚大学伦纳德·戴维斯卫生经济研究所之间的合作，将以一个跨学科学者小组的建立和工作为指导，该小组涵盖基础科学、传播学、伦理学、政策、医学、经济学、人类学、医学史和法学。

The studies proposed hold significant promise for the development of new, more efficacious tobacco treatment strategies. To realize this potential, we must identify and address potential barriers lthat mayarise in translating this research into clinical practice. We believe it is critical to address these issues concomitantly with the science, thereby improving the likelihood that new knowledge generated will be applied in clinical settings and contribute to reducing the burden of smoking on the nation?s health. Therefore, this Core will anticipate issues related to translation, begin some targeted investigations to address these questions and concerns, and communicate the potential clinical value of the TTURC research to key policymakers and other stakeholders in an effective manner. Our specific aims are: 1) To identify and prioritize key ethical, practical, economic, and policy issues related to the translation of TTURC research (for the 3 human studies) into improved tobacco dependence treatments. 2) To implement portions of this research agenda through policy analyses (3-4 commissioned papers) and pilot studies which begin to address these emerging policy and ethical issues. The pilot studies, supported through the TTURC Developmental Research Program, will generate preliminary data for future transdisciplinary R01 applications. 3) To develop a strategic communications plan and appropriate dissemination tools (issue and policy briefs, policy conference) for the 3 human studies to reach other scientists, policymakers, the media and the public. The Research to Practice Core represents a collaboration between the TTURC and the Leonard Davis Institute of Health Economics at Penn, and will be guided by the establishment and work of a transdisciplinary group of scholars spanning the basic sciences, communication, ethics, policy, medicine, economics, anthropology, history of medicine, and law.