DEVELOPMENTAL RESEARCH PROGRAM

黑色素瘤孢子发育研究计划的总体目标是支持黑色素瘤中有前途的试点转化研究，特别是那些将产生旨在降低黑色素瘤患者的发病率或死亡率或改善生活质量的临床可验证假设的项目。 创新转化研究的提案将由管理核心的SPORE执行委员会通过向休斯顿医学中心的所有机构发布公告来征求。执行委员会成员将帮助研究人员提交提案，以制定其翻译的具体目标和研究计划，因为这些研究人员中的许多人可能没有这方面的专业知识。因此，这一过程将是一个重大的教育活动，以进一步刺激黑色素瘤创新转化研究概念的发展。执行委员会将首先使用黑色素瘤研究重点的客观标准和预算理由对提案进行筛选，以获得适当的SPORE资格。 然后将提案转交给外部科学咨询委员会（EAB）成员。我们会根据评核委员会的评分，最后决定资助的研究项目。 这些项目将获得至少一年的资助，从本SPORE的第一年开始;根据进展和需要，可能会再延长一年。作为我们继续努力扩大黑色素瘤研究的一部分，在安德森癌症中心，2002年夏天在全机构范围内宣布并征求试点项目;在排除了被认为是纯基础科学的项目和几个被认为缺乏足够价值进行进一步审查的项目后，8个项目被确定为与SPORE的转化重点一致。这8项提案包括在其中，并代表了今年将审查供资考虑的提案，预计将资助4项提案。这8个项目说明了我们机构对黑色素瘤转化研究的兴趣的广度和深度。

The overall aim of the Melanoma SPORE Developmental Research Program is to support promising pilot translational studies in melanoma, particularly those projects that will generate clinically testable hypotheses aimed at reducing the incidence or mortality rate or improving the quality of life of patients with melanoma. Proposals for innovative translational research will be solicited by the SPORE Executive Committee of the Administrative Core by announcements to all institutions in the Houston Medical Center. The Executive Committee members will help investigators submitting proposals to formulate their translational specific aims and research plans, as many of these investigators may not have expertise in this area. The process will therefore be a major educational activity to further stimulate the development of innovative translational research concepts in melanoma. Proposals will be screened first for appropriate SPORE qualifications by the Executive Committee by using objective criteria of melanoma research focus and justification of budget. Proposals will then be forwarded to members of the External Scientific Advisory Board (EAB). On the basis of the scores received from the EAB, the final selection of the research projects for funding will be made. The projects will be funded for at least one year, beginning in year one of this SPORE; extensions may be awarded for an additional year based on progress and need. As part of our continuing efforts to expand melanoma research at M.D. Anderson Cancer Center, an institution-wide announcement and solicitation for pilot projects was made in the summer of 2002; after elimination of projects considered to be purely basic science and several considered to lack sufficient merit for further review, 8 were determined to be consistent with the translational focus of the SPORE. These 8 proposals are included within, and are representative of those that will be reviewed for funding consideration this year, and funding of 4 is predicted. These 8 projects illustrate the breadth and depth of interest in melanoma translational research at our institution.