CORE--CLINICAL

临床核心的主要目标是在ADRC招募和维持一个约400名志愿患者和对照组，以及100名志愿患者和对照组，作为我们在丘拉维斯塔卫星诊所的西班牙裔计划的一部分。核心研究将招募诊断为轻度认知障碍（MCI）和极早期AD（MMSE ≥ 20）的新受试者，以替换受损程度更高的受试者。将维持DRS评分大于或等于109的40例受试者的汇总，以满足我们研究方案的需求。在这个竞争性的更新周期中，我们将专门为Bondi博士的功能性MRI项目增加MCI受试者库至100人。将继续特别强调 因此，我们建议将研究重点放在招募80岁以上的正常对照组上，以满足临床病理学相关性和生化研究对更多尸检大脑的需求。年度参与者评估将包括人口统计学、病史、医学神经学、精神病学和神经心理学检查，以帮助诊断并跟踪认知和神经学进展的年度变化。这些评估提供了一个行为数据库，可用于与ADRC相关的各种研究项目，此外还提供了有关AD病程和进展的纵向数据。临床核心维护DNA，血浆，血清和CSF的银行，由各种UCSD研究人员和其他机构和行业的合作者使用。临床核心为参与各种多中心临床试验和使用受试者和数据的合作研究提供资源。最后，将开展开发工作，以提高我们诊断早期AD的能力，并改善其他痴呆症，如路易体痴呆症和额颞叶痴呆症的诊断。

The principal objective of the Clinical Core will be to recruit and maintain a panel of approximately 400 volunteer patients and controls at the ADRC, and 100 volunteer patients and controls as part of our Hispanic initiative at our satellite clinic in Chula Vista. The Core will recruit new subjects with a diagnosis of Mild Cognitive Impairment (MCI) and very early AD (MMSE greater than or equal to 20) to replace subjects who have become more impaired. A pool of 40 subjects will be maintained with DRS scores greater than or equal to 109 to meet the needs of our research protocols. During this competitive renewal cycle we will specifically increase our pool of MCI subject to 100 for Dr. Bondi's project on functional MRI. Particular emphasis will continue to be placed on the recruitment of normal controls over the age of 80, in order to meet the need for greater numbers of autopsied brains for clinical-pathotogical correlations and biochemical studies. Annual participant evaluations will include demographic, history, medical neurological, psychiatric, and neuropsychological examinations to aid in the diagnosis and to track yearly changes in cognitive and neurological progression. The evaluations provide a behavioral database that can be used by the various research projects associated with the ADRC and in addition provide longitudinal data on the course and progression of AD. The Clinical Core maintains banks of DNA, plasma, serum, and CSF, used by various UCSD investigators and collaborators at other institutions and in industry. The Clinical Core provides the resources for participation in a variety of multi-center clinical trials and collaborative studies using both subjects and data. Finally developmental work will be undertaken to improve our ability to diagnose early AD and to improve the diagnosis of other dementias such as dementia with Lewy bodies and fronto-temporal dementia.