In Vivo Imaging Neoplasia

描述(由申请人提供)： 活体细胞和分子成像中心的建立 (ICMIC)将提供科学家之间的多学科互动 位于范安德尔研究所和密歇根大学。ICMIC 将提供框架，将这些交互引导到完全 在分子成像领域的发展和新的应用。这些 在P20(前ICMIC)筹资阶段发生的相互作用， 已经在这方面产生了一些最有创意和最有洞察力的想法 快速发展的研究领域称为分子成像。此应用程序 寻求在这些成功的科学互动和实验的基础上 结果为了在肿瘤学成像方面取得重大进展。 这组调查人员勤奋工作，汇集了一个独一无二的 使用高度新颖的分子成像结构和 “报告”关键细胞和分子事件的成像方法 事件。这些事件包括致癌(项目2)、细胞凋亡(项目#)。 #1)、癌基因激活(项目3)、血管生成(试点项目1)和 转移(试点项目2)。无论是最初的生物事件还是 随后测量的生物反应可以使用以下方法进行无创监测 磁共振成像和光谱学(磁共振/S)，体内生物发光 成像(BLI)和正电子发射断层扫描(PET)。这是一个多学科的 和多模式方法将提供更全面的理解 导致肿瘤的转化过程中的综合事件 启动、进展、血管生成、转移、免疫反应和 总体治疗反应(或抵抗)。这些研究不仅将 为检测这些生物提供新的显像剂和方法 事件，但也将产生基因工程小鼠，将有 用于非侵入性和动态成像的报告基因 随着时间的推移，完好无损的动物中发生的事件。如上所述，三项研究 项目和两个试点项目随着职业生涯的发展而发展 开发计划和三个核心。职业发展计划提供 一个培养年轻人和热情的人并与之互动的绝佳机会 分子成像领域的研究人员。行政核心A 提供行政支持，包括内部和外部科学 对所有项目进行审查。小动物成像核心B提供 必要的专业知识和成像服务，包括microPET、MRI、microPET 活体BLI、放射自显影、放射性药物合成和数字图像 正在处理。转基因动物核心C提供了必要的专业知识和 集中资源，高效地生产新的和重要的 转基因小鼠成像模型。这项研究建议是一项 在目前的P20和R24 NCI支持下取得进展的自然结果。 在密歇根州建立一个世界领先的ICMIC是当务之急 密歇根大学和范安德尔研究所做出的承诺 研究所与密歇根州(通过生命分配的资金 科学走廊)，他们都与NIH一起做出了贡献，以便 提供必要的基础，确保这一至关重要的 引人入胜的努力。

DESCRIPTION (provided by applicant): The establishment of this In Vivo Cellular and Molecular Imaging Center (ICMIC) will provide for multidisciplinary interactions between scientists located at the Van Andel Institute and the University of Michigan. The ICMIC will provide the framework for channeling these interactions into fully developed and novel applications in the field of molecular imaging. These interactions, which have occurred during the P20 (Pre-ICMIC) funding stage, have already yielded some of the most creative and insightful ideas in this rapidly evolving area of research termed molecular imaging. This application seeks to build upon these successful scientific interactions and experimental results in order to provide for significant advances in oncologic imaging. This group of investigators has worked diligently to bring together a uniquely integrated approach using highly novel molecular imaging constructs and imaging approaches to "report" occurrences of key cellular and molecular events. These events include carcinogenesis (Project #2), apoptosis (Project #1), activation of oncogenes (Project #3), angiogenesis (Pilot Project #1) and metastasis (Pilot Project #2). Both the initial biological event and the subsequent measured biological response can be noninvasively monitored using magnetic resonance imaging and spectroscopy (MRI/S), in vivo bioluminescence imaging (BLI) and positron emission tomography (PET). This multidisciplinary and multimodality approach will provide for a more complete understanding of the integrated events involved in the transformation process leading to tumor initiation, progression, angiogenesis, metastasis, immune response, and overall therapeutic response (or resistance). These studies will not only provide new imaging reagents and approaches for detection of these biological events, but will also yield genetically engineered mice which will have reporter genes "built-in" for noninvasively and dynamically imaging these events in intact animals over time. As mentioned above, three Research Projects and two Pilot Projects have been developed along with a Career Development Program and three Cores. The Career Development Program provides a great opportunity to train and interact with young and enthusiastic investigators in the field of molecular imaging. The Administrative Core A provides administrative support including Internal and External Scientific review for all projects. The Small Animal Imaging Core B provides the necessary expertise and imaging services including microPET, MRI, microPET in vivo BLI, autoradiography, radiopharmaceutical synthesis and digital image processing. The Transgenic Animal Core C provides the necessary expertise and centralized resources for efficient production of novel and important genetically engineered mouse imaging models. This research proposal is a natural outgrowth of the progress made with current P20 and R24 NCI support. Establishment of a world-leading ICMIC in Michigan is a priority and commitment made by the University of Michigan and the Van Andel Research Institute along with the State of Michigan (funds allocated through the Life Sciences Corridor) who have all contributed together with the NIH in order to provide the foundation necessary for ensuring the success of this vital and intriguing endeavor.