NINDS Center Core for Brain Imaging

描述（由申请人提供）： 这项建议是在华盛顿大学建立NINDS脑成像中心核心（NCCBI）。该中心的目标是提高我们机构神经影像学研究的质量，多样性和利用率。随着NCCBI的成立，我们将能够实现以下具体目标： 1.很少或没有以前的成像经验和最低限度的成像资源的神经科学家将能够增加他们的研究与新的人类或动物的大脑成像实验使用最先进的技术和分析。我们确定了10个NINDS资助的研究项目（其中8个是由计划公告定义的合格项目），由这一类的研究人员领导。 2.具有成像经验和正在进行的成像项目的神经科学家作为一个群体，将能够大大扩展他们获得的成像测量的类型，提高成像数据的质量，并提高他们的成像研究的效率。我们确定了22个NINDS资助的研究项目（其中14个是合格的项目），由这一类的研究人员领导。 NCCBI将创建三个核心来实现这些目标：行政核心，放射化学核心和成像核心。行政核心将a）确保核心教师和神经科学界之间的高水平沟通，B）通过执行委员会管理资金和人力资源，c）接受新用户并通过指导委员会为核心活动设定优先级，d）组织包括客座讲师在内的系列讲座，以及e）为教职员工和用户维护一个网页，以便能够对成像应用进行持续讨论。放射化学核心将建立一个放射化学实验室，以实现PET放射性示踪剂的转化神经科学研究。这将通过以下方式实现：a）利用东楼回旋加速器-放射化学设施内的新空间，以支持神经科学中的PET研究; B）建造专用于参与NCCBI的研究者的研究需求的自动合成系统;以及c）雇用新人员进行放射性药物生产的设计、维护和运行。成像核心将提供广泛的服务，以提高脑成像研究的可用性，包括a）关于新成像研究方案的设计和实施的培训系列和咨询，B）图像数据的中央数据管理工具，c）访问PET和MR数据的自动和半自动处理例程，以及d）随着新成像技术的发展，协助新成像技术的验证和传播，包括扩散张量成像、扩散张量跟踪和MRS中的那些。

DESCRIPTION (provided by applicant): This proposal is to create the NINDS Center Core for Brain Imaging (NCCBI) at Washington University. The goal of this Center will be to enhance the quality, diversity and utilization of neuroimaging research at our institution. With the creation of the NCCBI we will be able achieve the following specific aims: 1. Neuroscientists with little or no previous imaging experience and minimal access to imaging resources will be able to augment their research with new human or animal brain imaging experiments using state-of-the art technologies and analyses. We identify ten NINDS-funded research projects (eight of which are qualifying projects as defined by the program announcement) headed by investigators in this category. 2. Neuroscientists with imaging experience and ongoing imaging projects will, as a group, be able to substantially expand the type of imaging measures they obtain, improve the quality of the imaging data, and increase the efficiency of their imaging research. We identify 22 NINDS-funded research projects (14 of which are qualifying projects) headed by investigators in this category. The NCCBI will be created with three cores to achieve these aims: an Administrative Core, Radiochemistry Core, and Imaging Core. The Administrative Core will a) insure a high level of communication between the core faculty and the neuroscience community, b) administer the funding and personnel resources through an Executive Committee, c) accept new users and set priorities for Core activities through a Steering Committee, d) organize a Lecture Series including Visiting Lecturers, and e) maintain a Web page for faculty and users to enable ongoing discussions on imaging applications. The Radiochemistry Core will establish a radiochemistry laboratory to enable translational neuroscience research with PET radiotracers. This will be achieved with a) utilization of new space within the East building cyclotron-radiochemistry facility to support PET research in the neurosciences, b) construction of automated synthesis systems dedicated to the research needs of the investigators participating in the NCCBI, and c) hiring of new personnel for design, maintenance and running of radiopharmaceutical production. The Imaging Core will provide a broad spectrum of services to increase availability of brain imaging research including a) Training Series and consultation on design and implementation of new imaging research protocols, b) central data management tools for image data, c) access to automated and semi-automated processing routines for both PET and MR data, and d) assistance in the validation and propagation of new imaging techniques as they are developed, including those in diffusion-tensor imaging, diffusion-tensor tracking, and MRS.