Integrative Examination of Comorbidity with ADHD

描述（由申请人提供）：这份博士前研究支持申请的结构是为了让申请人准备好竞争精神病学和遗传流行病学的研究型教师职位。具体而言，培训和指导研究经验将侧重于结合流行病学，统计学和行为遗传学方法来研究儿童精神障碍共发的病因。将检查障碍聚类、严重程度、共同遗传影响和结果，以评估共病精神病理与注意缺陷多动障碍（ADHD）的关系。ADHD是一种以多动、冲动和注意力不集中为特征的多维障碍，因此外化和内化障碍可能以不同的方式同时发生。基因或环境都可能以不同的方式影响这些疾病的病因及其排列。该博士预科奖学金将允许申请人：1)对两个现有数据集进行二次数据分析，采用现代统计方法系统地检查ADHD的共病和对障碍聚类的影响；2)完成这些方法的课程和培训，精神病学流行病学，并获得分子遗传学的介绍。

DESCRIPTION (provided by applicant): This pre-doctoral research support application is structured to prepare the applicant to compete for a research-oriented faculty position in psychiatric and genetic epidemiology. Specifically, training & supervised research experience will focus on combining epidemiologic, statistic, & behavior genetic methods to study the etiology of child psychiatric disorder co-occurrence. Disorder clustering, severity, shared genetic influence, & outcomes will be examined to assess the relationship of comorbid psychopathology with Attention Deficit Hyperactivity Disorder (ADHD). ADHD is a multi-dimensional disorder characterized by symptoms of hyperactivity, impulsivity, & inattention, thus, externalizing & internalizing disorders may co-occur differentially. Genes or the environment both likely influence the etiology of these disorders & their permutations in different ways. This pre-doctoral fellowship award will allow the applicant to: 1) conduct secondary data analysis of two existing datasets to systematically examine comorbidity with ADHD & influences on disorder clustering employing contemporary statistical methodology & 2) complete coursework & training in these methods, psychiatric epidemiology, & gain an introduction to molecular genetics.