TRAINING GRANT IN MUCOSAL IMMUNOLOGY AND EPIDEMIOLOGY

EXCEED提供的空间。这笔培训赠款将支持父母国际传染病研究合作奖的研究和培训目标，题为“孟加拉国对霍乱弧菌感染的免疫反应”。在ICIDR奖中，我们建议在世界霍乱弧菌感染的地方性地区调查黏膜免疫反应中对霍乱具有保护作用的那些成分，并在多变量分析中将这些成分与细菌和宿主因素相关联。我们有两名主要的外国合作者，一名高级免疫学家和一名孟加拉国达卡国际腹泻病研究中心(ICDDR，B)的高级流行病学家。ICDDR，B是国际公认的腹泻疾病研究机构。然而，该机构以及整个孟加拉国都迫切需要培训更多的现代免疫学和流行病学技术科学家。在这笔培训赠款中，我们建议在孟加拉国确定两名博士级别的卫生专业人员，他们将来美国接受为期两年的培训。一名学员将专注于免疫学研究，并将在马萨诸塞州总医院PI的基础研究实验室工作两年，学习粘膜免疫学技术，如ELISA和抗体分泌细胞分析、杀弧菌抗体测量，并与相关动物模型合作。另一名学员将专注于流行病学，在第一年的培训中，将在哈佛公共卫生学院攻读传染病流行病学专业的理学硕士学位课程。在第二年，这个人将在孟加拉国进行流行病学研究，直接支持母公司ICIDR赠款的研究和培训目标，并在孟加拉国和美国的培训教师的共同监督下进行。该项目的候选人最初将由我们在孟加拉国ICDDR，B的合作者确定，然后将与美国培训教师共同挑选。我们作出决定的一个重要考虑因素将是这些人在培训结束后返回孟加拉国工作的承诺，以及孟加拉国的一个机构(如复员和重返社会国际委员会，B)为他们提供一个职位的承诺。这笔培训赠款的目的是加强孟加拉国的科学和公共卫生基础设施，并支持母公司ICIDR奖的研究目标。表演网站========================================Section End===========================================

EXCEEDTHE SPACE PROVIDED. This training grant would support the research and training goals of the parent International Collaborations in Infectious Disease Research (ICIDR) Award, entitled "Immune responses to V. cholerae infection in Bangladesh". In the ICIDR Award, we proposed to investigate those components of the mucosal immune response that are protective against cholera in an area of the world endemic for V.cholerae infection, and to correlate these components in a multivariate analysis with bacterial and host factors. We have two major foreign collaborators, a senior immunologist and a senior epidemiologist at the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh (ICDDR,B). The ICDDR,B is an internationally recognized facility for research in diarrheal diseases. However, there is a strong need at this institution, as well as in the country of Bangladesh overall, to train additional scientists in modern techniques of immunology and epidemiology. In this training grant, we propose to identify two doctoral level health professionals in Bangladesh, who will come to the US for training for a period of two years each. One trainee will focus on immunology research and will spend two years in the Pi's basic research laboratory at the Massachusetts General Hospital, learning mucosal immunological techniques such as ELISA and antibody-secreting cell assays, vibriocidal antibody measurements, and work with relevant animal models. The other trainee will focus on epidemiology and for the first year of training, will enroll in the Masters of Science in Epidemiology Degree program at the Harvard School of Public Health, in the Infectious Disease Epidemiology track. In the second year, this individual will do an epidemiological study in the field, in Bangladesh, in direct support of the research and training aims of the parent ICIDR grant, and under the joint supervision of the training faculty in both Bangladesh and the US. Candidates for this program will initially be identified by our collaborators at the ICDDR,B in Bangladesh and then will be jointly selected with the US training faculty. An important consideration for our decisions will be the commitment of the individuals to return to work in Bangladesh at the completion of training and the commitment of an institution in Bangladesh (such as the ICDDR,B) to give them a position. The intent of this training grant is to strengthen the scientific and public health infrastructure in Bangladesh and support the research aims of the parent ICIDR Award. PERFORMANCE SITE ========================================Section End===========================================