Synthesis of new types of nanoparticles and their antimicrobial resistance

抗菌素耐药性（AMR）是全球最严重的威胁之一，每年在欧盟/英国有超过25，000名患者死亡，预计到2050年，AMR细菌将杀死超过1000万人。在经济上，预计未来40年全球GDP损失将超过5万亿英镑。该项目的主要目标将是合成新型纳米颗粒，这些纳米颗粒将靶向并杀死世界卫生组织优先名单上的病原体。Kanaras集团（http：//www.licn.phys.soton.ac.uk/）在纳米颗粒功能化和纳米颗粒-细胞相互作用方面享有国际声誉和专业知识。最近，该小组开发了化学方案，以合成和功能化具有生物活性分子（如肽，蛋白质和DNA）的各种类型的纳米颗粒，这些纳米颗粒具有多任务作用，如选择性传感和杀死癌细胞，抑制血管生成和增强皮肤渗透。成功的申请人将获得跨化学，物理和生物学领域的多学科专业知识，利用广泛的表征技术

Antimicrobial Resistance (AMR) is one of the most serious threats globally with more than 25,000 patients dying in the EU/UK annually, and it is predicted that AMR bacteria will kill >10 million people by 2050. Economically, the loss to global GDP is predicted to be > £5 trillion over the next 40 years.The main objective of this project will be to synthesize new types of nanoparticles which will target and kill pathogens that they are at the priority list of the World Health Organization. The Kanaras group (http://www.licn.phys.soton.ac.uk/) has an international reputation and expertise in nanoparticle functionalization and nanoparticle-cell interactions. Recently, the group has developed chemical protocols to synthesize and functionalize various types of nanoparticles with bioactive molecules such as peptides, proteins and DNA, which possess multi-tasking roles such as selective sensing and killing of cancer cells, inhibition of angiogenesis, and enhanced skin penetration. The successful applicant will gain multidisciplinary expertise across the areas of chemistry, physics and biology utilizing a broad range of characterization techniques