SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER

描述(由申请人提供)：P51 RR00163-45助学金的5年续期要求为支持ONPRC生物医学研究的项目提供资金。该申请反映了动物资源和研究服务核心的显著扩大，这是支持研究项目增长所需的(外部赠款资金在过去5年中翻了一番)，并极大地扩大了印度衍生的无特定病原体(SPF)恒河猴繁育群体。 这项申请的目的是：1)提供必要的基础设施支持，以开展先进的生物医学研究，其中非人类灵长类动物(HEP)被用于加速了解人类疾病的进展，导致更好的健康；2)增强中心的资源(科学专业知识、实验室、动物服务、研究服务核心和设备)，以作为区域、国家和国际资源；3)通过支持我们的计划，增加用于生物医学研究的已定义HEP的可用性；该计划扩展SPF印度来源的恒河猴育种计划，该计划生产出没有病毒，如B疱疹病毒，并具有明确的亲缘关系和基因的动物；以及4)扩大利用NHP在遗传学、传染病和疫苗开发、老龄化、神经科学和妇女健康方面的研究项目。为了实现这些目标，需要在四个主要领域提供支持。行政和中心业务提供了ONPRC所有方面所需的行政和服务支持。单位包括处长办公室、商务事务、设施和财产以及信息技术和工程。研究基础设施包括提供最先进研究支持的服务单位，如动物资源(商业和研究协调、临床医学、NHP资源、运营、病理服务、心理健康和外科服务)、研究服务核心(辅助生殖技术、电生理学、内分泌服务、流式细胞术、成像和形态、分子和细胞生物学、单抗、研究图书馆和病毒学)和特殊资源计划(替代NHP物种、遗传学资源和信息学、老龄NHP和恒河猴育种)。科学资源包括支持ONPRC科学家所在的三个研究部门：病理生物学和免疫学部门、神经科学部门和生殖科学部门。还要求为4个与资源有关的研究项目和试点项目方案提供资金。改善和现代化包括用于设备和改建和翻新的资金。申请的资金将用于支持所需的研究基础设施，以使用NHP作为人类健康和疾病的模型进行最先进的生物医学研究，并满足NHP模式至关重要的新兴研究领域的需求，如功能基因组学和生物防御倡议。

DESCRIPTION (provided by applicant): The 5-year renewal for Grant P51 RR00163-45 requests funding for programs that support biomedical research at the ONPRC. The application reflects a significant expansion in animal resources and research service cores that is required to support the growth in research programs (external grant funding has doubled during the past 5 years) and to greatly expand the Specific Pathogen Free (SPF) Indian-derived Rhesus Breeding Colony. The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which nonhuman primates (NHPs) are used to accelerate progress in understanding human diseases, leading to better health; 2) enhance the Center's resources (scientific expertise, laboratories, animal services, research service cores and equipment) so as to serve as a regional, national and international resource; 3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-derived Rhesus macaque breeding program that produces animals free of viruses such as herpes B and with defined parentage and genotype; and 4) expand research programs utilizing NHPs in genetics, infectious diseases and vaccine development, aging, neuroscience and women's health. To accomplish these aims, support is requested in four broad areas. Administration and Center Operations provide the administrative and service support that is required for all aspects of the ONPRC. Units include the Director's Office, Business Services, Facilities and Property, and Information Technology and Engineering. Research Infrastructure encompasses the service units that provide the most technologically advanced research support, such as Animal Resources (Business and Research Coordination, Clinical Medicine, NHP Resources, Operations, Pathology Services, Psychological Well Being and Surgery Services), Research Service Cores (Assisted Reproductive Technology, Electrophysiology, Endocrine Services, Flow Cytometry, Imaging and Morphology, Molecular and Cellular Biology, Monoclonal Antibody, Research Library, and Virology) and Special Resources Programs (Alternative NHP Species, Genetics Resource and Informatics, Aging NHPs and Rhesus Breeding). Scientific Resources includes support for the three research divisions that house ONPRC scientists: the Divisions of Pathobiology and Immunology, Neuroscience, and Reproductive Sciences. Funding is also requested for 4 resource-related research projects and the pilot project program. Improvement and Modernization includes funds for equipment and alterations and renovations. The funds requested will provide support for the research infrastructure that is required to conduct the most advanced biomedical research using NHPs as models of human health and disease, and to meet the needs of new emerging areas of research in which the NHP model is critical, such as functional genomics and biodefense initiatives.