Neural representation of memory for the order of events

描述（由申请人提供）：为了探索海马区介导陈述性记忆的神经编码机制，将记录行为大鼠的单个神经元，当它们对一系列刺激项目进行采样时，然后判断样本列表上项目的顺序或熟悉程度。我将检验这样一个假设，即海马体编码有关项目顺序位置的信息，而相邻的周围皮层编码项目熟悉度（即，该项目是否在列表上）。拟议的实验以最近对人类的发现为指导，这些发现被认为是海马体在情景记忆和周围皮层在语义记忆中选择性作用的证据。此外，最近在动物身上的发现表明，序列记忆是海马参与情景记忆的一个重要特征。对海马体和周围皮层的神经元编码长期记忆的机制的基本理解是理解陈述性记忆和解决记忆障碍的基础。

DESCRIPTION (provided by applicant): To explore the neural coding mechanisms by which the hippocampal region mediates declarative memory, single neurons will be recorded in behaving rats as they sample a series of stimulus items, then judge either the sequential order or the familiarity of the items on the sample list. I will test the hypothesis that the hippocampus encodes information about the sequential positions of the items whereas the adjacent perirhinal cortex encodes item familiarity (i.e., whether or not the item was on the list). The proposed experiments are guided by recent findings with humans that have been taken as evidence for a selective role for the hippocampus in episodic memory and for the surrounding cortex in semantic memory. Also, recent findings in animals suggest sequence memory is an important feature of hippocampal involvement in episodic memory. A basic understanding of the mechanisms by which long-term memories are encoded by neurons in the hippocampus and surrounding cortex is fundamental to understanding declarative memory and to addressing disorders of memory.