Genetic Mechanisms of Cardiac Disease in the Young

描述(由申请人提供)： 应聘者是一名儿科心脏病专家，职业生涯长期致力于以患者为中心的研究。1995年，他在哈佛医学院塞德曼实验室接受了为期31个月的博士后研究员培训，成为一名人类分子遗传学家。他于2001年1月被招募到辛辛那提儿童医院，在儿科心脏病学的临床项目和分子心血管生物学的心脏开发项目之间架起一座桥梁。他的长期研究目标是确定儿童心脏病的分子基础。这一续签申请旨在为候选人在以患者为导向的研究中为儿科心脏病学导师研究员提供支持。支持这项拟议研究的资金由儿童心脏病SCCOR(PI，Benson)和项目项目赠款(PI，Gourdie)提供。提出了三个新的以患者为导向的研究项目，这些项目将得到这笔赠款的特别支持。这项研究的目的是基于初步数据所证明的理论基础和可行性而制定的。拟议的计划将为儿科心脏病学研究员提供以患者为导向的研究指导，但为了努力增加儿科心脏病学的申请者池，将指导拥有医学博士-博士学位的博士后学生或博士后实习生。机构环境丰富，心血管研究，博士后和博士后水平的培训计划是实质性的。辛辛那提儿童医学中心有一个完善的以病人为导向的研究计划。有慷慨的机构支持来建立先天性心脏病的分子遗传学项目。所有要素都已组装起来，以建立一个丰富的环境，指导以患者为导向的研究人员在青少年心血管疾病的分子遗传学方面的研究。获得以患者为中心的研究生涯中期奖将允许候选人将50%的精力投入到以患者为中心的研究和指导上。

DESCRIPTION (provided by applicant): The Candidate is a pediatric cardiologist with a career long commitment to patient-oriented research. In 1995 he retrained as a human molecular geneticist during a 31-month-long postdoctoral fellowship in the Seidman Laboratory, Harvard Medical School. He was recruited to Cincinnati Children's Hospital in January 2001 to build a bridge between the clinical programs in Pediatric Cardiology and the cardiac development programs in Molecular Cardiovascular Biology. His long-term research objective is to determine the molecular basis of pediatric heart disease. This renewal application is designed to provide the Candidate with support to mentor Fellows in Pediatric Cardiology in patient-oriented research. Funding to support the proposed research is provided by a SCCOR in Pediatric Heart Disease (PI, Benson) and a project on a Program Project Grant (PI, Gourdie). Three new patient-oriented research projects to be specifically supported by this grant are proposed. The aims of the research have been developed based upon the rationale and feasibility demonstrated in preliminary data. The proposed program will provide mentoring in patient-oriented research for Pediatric Cardiology Fellows, but in an effort to increase the applicant pool in Pediatric Cardiology, predoctoral students or postdoctoral trainees with M.D.-Ph.D. will be mentored. The institutional environment is rich in cardiovascular research, and the pre- and postdoctoral level training programs are substantial. A well-established patient-oriented research program exists at the Cincinnati Children's Medical Center. There is generous institutional support to establish a program for molecular genetics of congenital heart disease. All elements have been assembled for building an enriched environment for mentoring patient-oriented research investigators in molecular genetics of cardiovascular disease in the young. Receipt of the Mid-Career Award in patient-oriented research will allow the Candidate to devote 50% effort to research and mentoring in patient-oriented research.