RNA-Based Approaches in Cardiovascular Disease

摘要 请求支持一个名为“基于RNA的心血管方法”的Keystone研讨会会议 疾病，由托马斯图姆和罗杰J.哈贾尔博士组织。会议将在Keystone举行， 科罗拉多，2017年3月26日至30日。心脏病是全世界的主要死因。基于rna 机制和治疗方法是心血管科学的新兴领域。本次会议将 介绍和讨论使用编码RNA和非编码RNA的最新进展-（如microRNA， 长链非编码RNA和环状RNA）为基础的方法，以更好地了解和开发新的 心脏疾病的治疗策略。与会者将受益于研讨会，具体会议和 从基础科学到使用RNA的临床翻译， 心血管医学的治疗学。跨学科互动的机会将大大增加。 同时举行的心脏发育分子机制会议加强了这一点，会议将分享一个 本次会议有两个主题演讲和两次全体会议。 与NHLBI的相关性：心血管疾病（CVD）是美国发病率和死亡率的主要原因。 states. NHLBI的战略使命之一是，在识别CVD的同时， 新的潜在目标。基于对信号传导的更好理解， 参与心血管疾病发病机制的途径。将基因靶向心脏， microRNA和基于RNA的递送有可能改变我们治疗心血管疾病患者的方法。 疾病这次会议将汇集来自各种渠道的科学家。通过这种结合 在具有多学科背景的研究人员中，将重点关注不同的科学观点， 心血管疾病

ABSTRACT Support is requested for a Keystone Symposia meeting entitled RNA-Based Approaches in Cardiovascular Disease, organized by Drs. Thomas Thum and Roger J. Hajjar. The meeting will be held in Keystone, Colorado from March 26-30, 2017. Cardiac diseases are the leading cause of death worldwide. RNA-based mechanisms and therapeutic approaches are emerging fields in cardiovascular science. This meeting will present and discuss latest developments using both coding RNA and noncoding RNA- (such as microRNAs, long noncoding RNAs and circular RNAs) based approaches to better understand and develop new therapeutic strategies for cardiac diseases. Attendees will benefit from workshops, specific sessions and industrial perspectives covering everything from basic science to clinical translation employing RNA therapeutics in cardiovascular medicine. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Molecular Mechanisms of Heart Development, which will share a keynote address and two plenary sessions with this meeting. Relevance to NHLBI: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in the United States. Among the NHLBI’s strategic mission is the goal to advance our knowledge of CVD while identifying new potential targets. Novel treatments are being formulated based on a better understanding of the signaling pathways involved in the pathogenesis of cardiovascular diseases. Targeting genes to the heart through microRNA and RNA based deliveries have the potential to alter our approach to patients with cardiovascular diseases. This meeting will bring together scientists from a wide array of avenues. Through this combination of investigators with multidisciplinary backgrounds, diverse scientific perspectives will be brought into focus on cardiovascular diseases.