Clinical and Bioinformatics Core

该核心将负责确定中心研究的所有参与者。这一核心将确定潜在的参与者，联系他们参与，并将他们纳入研究。核心中心将帮助安排在诊所或家中的预约。他们还将招收家长。中心还将对每位参与者进行多次评估，并抽取血液样本进行DNA提取。杜克大学和范德比尔特大学的核心部门之间将进行实质性的协调。此外，该核心将提供生物信息学支持，将作为中心一部分收集的所有相关临床、病史、家族史和基因信息建立数据库。已在DUMC和VUMC两个地点安装的PEDIGENE@系统将用作主要数据库系统。PEDIGENE@已经被用于许多其他项目，并已进行了10多年的现场测试。

This Core will be responsible for identifying all the participants in the studies of the Center. This core will identify potential participants, contact them for participation, and enroll them in the study. The core will help arrange appointments either in the clinics or in the home. They will also enroll parents. The Core will also perform numerous assessments on each of the participants, and draw blood samples for DNA extraction. There will be substantial coordination between the Duke and Vanderbilt arms of the Core. In addition, this Core will provide the bioinformatics support to database all the relevant clinical, medical history, family history, and genotypic information collected as part of the Center. The PEDIGENE@ system, already in place at both the DUMC and VUMC sites, will be used as the primary database system. PEDIGENE@ is already being used for numerous other projects and has been field tested for over 10 years.