Genetic and Environmental Influences on Personality, Drinking Motives, and Alcoho

描述(由申请人提供)： 项目摘要/摘要长期目标：这项建议的主要目标是从寿命的角度来研究遗传和环境因素如何影响和交互影响有问题的饮酒、个性和饮酒动机。最终，这个项目的目标是提供关于基因和环境如何促进酒精参与、个性和动机的进一步信息，以及基因和环境在多大程度上解释这些结构之间的关系。具体目标：这项建议的主要目的是前瞻性地检查与问题酒精参与有关的人格结构和饮酒动机的测量的基因-环境相关性和相互作用，并进一步确定这些因素与问题酒精参与的关系的测量的基因-环境相关性和交互作用的程度。这些分析将在包括基因数据的两个多波数据集中进行。意义：该项目的结果可以为改进识别、治疗和预防酒精使用障碍的方法提供信息，并可以澄清基因-环境的相关性和相互作用如何影响与酒精相关的个性、动机和行为。 公共卫生相关性： 项目叙述相关性：简而言之，拟议的研究项目可以帮助研究人员和临床医生更好地了解遗传风险如何与环境暴露相互作用，以影响与酒精问题相关的个性和饮酒动机。这些信息可以用来设计考虑遗传风险和环境因素的个体差异的治疗方法，以便更好地解决饮酒问题。

DESCRIPTION (provided by applicant): Project Summary/Abstract Long-Term Objectives: The primary goal of this proposal is to use a lifespan perspective to examine how genetic and environmental factors influence, and interact to influence, problematic alcohol involvement, personality, and drinking motives. Ultimately, the goal of this project is to provide further information on how genes and environment contribute to alcohol involvement, personality, and motives, and to what extent genes and environment explain the relations among these constructs. Specific Aims: The primary aims of this proposal are to prospectively examine measured gene-environment correlations and interactions that contribute to personality constructs as well as drinking motives related to problematic alcohol involvement, and to further determine the extent to which measured gene-environment correlations and interactions contributing to personality and drinking motives account for the relation of these factors with problematic alcohol involvement. These analyses will be conducted in two, multiwave datasets that include genotypic data. Significance: The results from this project could provide information towards improved approaches for identifying, treating, and preventing alcohol use disorders and could clarify how gene-environment correlations and interactions influence alcohol relevant personality, motives, and behaviors. PUBLIC HEALTH RELEVANCE: Project Narrative Relevance: Briefly, the proposed research project can help researchers and clinicians better understand how genetic risk interacts with environmental exposures to influence personality and drinking motives related to alcohol problems. This information can be used to design treatments that consider individual differences in genetic risk as well as environmental factors in order to better address problem drinking.