Enhance Facilities for Infectious Disease Imaging

描述（由申请人提供）：本提案要求资金用于完成用于BSL- 3病原体和选择剂工作的成像设施的建设，并为成像设施和传染病研究中心的其余部分提供地下电力供应。成像设施将位于科罗拉多州立大学山麓校区的贾德森M.哈珀研究中心。它将成为传染病研究中心（IDRC）的一部分，毗邻落基山地区生物控制实验室（RMRBL）。成像设施最初是研究创新中心建设项目的一部分，但在建筑设计开发阶段的预算限制导致大学对成像设施进行了核心和外壳。该请求将使该成像设施得以完成，并为该中心最先进的成像设备、高科技测序和分析实验室机器、HVAC和安全/安保需求提供安全、稳定和可靠的主要电力供应。该项目的完成将为大学和生物医学研究界带来以下好处。1）. 将为BSL-2和BSL-3传染病研究开辟新的空间。2）. 成像设施将通过提供实时体内图像，为传染病研究中心正在进行的新疗法和设备的转化阶段研究提供诊断信息。3）. 成像设施的扩建将为动物设施提供空间，并允许在BSL-3封闭环境中进行成像。4)。成像设施将建在一个安全的、可控制的设施内，确保在BSL-3条件下安全地进行动物实验。5)。成像设施的建设（本提案的具体目标1）将改善phs资助研究项目的实施，并大大扩大校园生物医学实验的范围和性质。目前使用RMRBL的研究人员是落基山地区生物防御和新兴传染病研究卓越中心（RMRCE）的成员，成像设施将大大加强他们的研究项目。蛋白质组学/基因组学实验室是RMRCE的一个核心实验室，经常受到电力波动和中断的影响，本提案的具体目标2将解决这一缺陷。6)。成像设施的建成将增强可用于生物医学研究的网络环境，例如捕获感染和未感染动物的高分辨率图像，无论是在它们患病时还是作为治疗剂干扰或预防传染病的进展时。

DESCRIPTION (provided by applicant): This proposal requests funds to complete construction of an Imaging Facility devoted to work with BSL- 3 pathogens and Select Agents and to provide an underground electrical feed to the Imaging Facility and the rest of the Infectious Disease Research Center. The Imaging Facility will be located within the Judson M. Harper Research Complex on the Foothills Campus of Colorado State University. It will be part of the Infectious Disease Research Center (IDRC), adjacent to the Rocky Mountain Regional Biocontainment Laboratory (RMRBL). The Imaging Facility was originally part of a Research Innovation Center construction project, but budgetary constraints at the Design Development phase of construction caused the University to core-and-shell the Imaging Facility. This request will allow the completion of this Imaging Facility and provide an essential main electrical feed to supply secure, steady and reliable power for state-of-the-art imaging equipment, high-technology sequencing and analytical laboratory machines, HVAC, and safety/security needs at the Center. Completion of this project will provide the following benefits to the University and the biomedical research community. 1). New space will be created for BSL-2 and BSL-3 infectious disease research. 2). The Imaging Facility will enable the generation of diagnostic information on translational stage studies of new therapeutics and devices taking place in the Infectious Disease Research Center by providing real-time in vivo images. 3). The Imaging Facility build-out will provide space for animal facilities and allow imaging within a BSL-3 contained environment. 4). The Imaging Facility will be constructed within a secure, controlled-access facility, assuring the safe conduct of animal experiments under BSL-3 conditions. 5). Construction of the Imaging Facility (Specific Aim 1 of this proposal) will improve the conduct of PHS-funded research projects, and greatly expand the scope and nature of biomedical experiments conducted on campus. Researchers currently using the RMRBL are members of the Rocky Mountain Regional Center of Excellence in Biodefence and Emerging Infectious Disease Research (RMRCE), and the Imaging Facility will enhance their research programs dramatically. The Proteomics/Genomics Laboratory, a core laboratory of the RMRCE, has been impacted by frequent power fluctuations and interruptions, a deficiency that will be addressed by Specific Aim 2 of this proposal. 6). Completion of the Imaging Facility will enhance the networked environment available for biomedical research, such as capture of high-resolution images of infected and uninfected animals, both as they develop disease and as therapeutic agents interfere with or prevent the progression of infectious diseases. CSU's commitment to sustainable building is evidenced by seven concurrent LEED gold buildings under construction, one of which is the Research Innovation Center on the Foothills Campus. The University has also recently launched a College for Global Environmental Sustainability, and the University administration has issued directives towards achieving energy neutral buildings by offsetting conventional supplies with solar and wind sources. The current project will be LEED certified. An economic model determined that this project will directly support 59 full-time jobs with an additional 37.4 spin-off positions, generating $4,630,895 in total payroll in the first year, and $406,298 in total ongoing economic impact from job creation. This proposal requests funds ($6,230,546) for an integrated project of completing a core-and-shell research facility plus providing vital electric infrastructure. Equipment requested include Techiplast animal caging and transfer racks for mice, Thoren caging and transfer racks for guinea pigs, biological safety cabinets designed and equipped for animal cage changing and animal manipulation, and shielding equipment required for work with radioactive materials associated with PET/CT imaging. Rationale: The Infectious Disease Imaging Facility will provide a unique capability that will be an important resource unavailable elsewhere in the Rocky Mountain region, and add to the limited national capabilities currently available. This Facility will vastly improve the research tools available to a very strong infectious disease research community in Fort Collins, and will be of major interest to biotechnology/discovery companies, federal bioscience departments and laboratories, both regionally and nationally. Completion of the underground power feed will address a long-standing concern about the lack of a secure, redundant power feed to the Regional Biocontainment Laboratory, greatly enhance the security of the complex, and provide a steady, reliable, and uninterrupted power source.