Laboratory renovation for translational synthetic and medicinal chemistry

描述（由申请人提供）：波士顿大学提议实施四个实验室模块的改造计划，包括位于大学查尔斯河校区（CRC）的梅特卡夫科学与工程中心的6700平方英尺的研究和支持空间。这个翻新的空间将直接支持合成和药物化学的研究工作，主要包括三个方面：波士顿大学分子发现中心（BU-CMD），化学方法和图书馆发展中心（CMLD-BU），以及在化学系招聘两名专注于生物化学的教师。这些改造将解决现有研究空间的三个关键问题：(1)暖通空调系统不充分或无功能，不节能或不灵活；(2)在没有承包商支持的情况下无法改变的恶化和不灵活的案例；(3)分隔实验室布局，限制了空间的重新分配，以实现研究需求的优化使用。为支持最先进的有机合成而设计的研究实验室的大规模扩展，利用灵活的实验室布局，使技术促进药物化学，是该计划的关键要素。将开发教师办公室和会议空间的互补发展，充分支持真实和虚拟会议，以促进研究科学家之间的参与和合作。虽然C06基金的申请将明显提高波士顿大学在化学和生物学界面进行生物医学研究的能力，但拟议的项目与美国复苏和再投资法案（ARRA）的目标是一致的。除了需要大量购买建筑材料和研究设备外，这项耗资590万美元的改造计划将为建筑和生命科学行业创造就业机会，这两个行业在马萨诸塞州联邦受到经济衰退的严重影响。在设计和施工过程中，将创造或维持15个与建筑、工程、建设相关的工作岗位。它还将为化学系另外20名科学研究人员提供实验室空间。

DESCRIPTION (provided by applicant): Boston University proposes to implement plans for the renovation of four laboratory modules consisting of 6,700 square feet of research and support space in the Metcalf Center for Science and Engineering on the University's Charles River Campus (CRC). This renovated space will directly support research efforts in synthetic and medicinal chemistry in three major undertakings: the Boston University Center for Molecular Discovery (BU-CMD), the Center for Chemical Methodology and Library Development (CMLD-BU), and the recruitment of two faculty with a biological chemistry focus in the Department of Chemistry. These renovations will solve three critical problems with the existing research space: (1) Inadequate or non-functional HVAC systems that are not energy efficient or flexible; (2) Deteriorating and inflexible casework that cannot be altered without contractor support; and (3) Compartmentalized laboratory layouts that limit the reassignment of space for optimal use as research needs evolve. The substantial expansion of research laboratories designed to support state-of-the-art organic synthesis, utilizing a flexible laboratory layout that will enable technology- facilitated medicinal chemistry, is a key element of the plan. Complementary development of faculty office and meeting space that fully supports real and virtual conferencing will be developed to facilitate engagement and collaboration between research scientists. While this request for C06 funding will clearly increase Boston University's ability to conduct biomedical research at the interface of chemistry and biology, the proposed project is consistent with the goals of the American Recovery and Reinvestment Act (ARRA). Besides requiring significant purchases in construction materials and research equipment, this $5.9 million renovation proposal will contribute jobs to the construction and life sciences industries, two key sectors in the Commonwealth of Massachusetts that have been significantly impacted by the economic downturn. During design and construction, the project will create or maintain 15 jobs related to the architectural, engineering, and constructions industries. It will also provide laboratory space for an additional 20 scientific researchers in the Department of Chemistry.