Translational Hematology and Oncology Research Laboratory Expansion Project

简介（由申请人提供）：在过去的十年中，克利夫兰诊所陶西格癌症研究所（TCI）在癌症治疗、临床试验和转化癌症研究方面取得了巨大的发展。这一扩建最初是在2000年搬到一座新大楼后实现的，其中四楼是癌症研究所的研究实验室。最初，实验室是在血液学和肿瘤分子治疗中心内管理的，但在获得研究资金，实验室成分的新临床试验和转化癌症研究人员的招募方面的成功，导致了由Jaroslaw Maciejewski博士领导的新的转化血液学和肿瘤研究部门（THOR）的形成。目前，物理设施包括pi的实验室，共享设备区，会议室，工作人员和行政办公室以及血液学/肿瘤学和博士后研究员的房间。目前，45名科学技术人员和10名支持研究人员占用了可用的空间，其容量已经耗尽。在2000年新楼建成之前，癌症研究所的研究人员占据了医院相邻的M楼的实验室，现在通过一座桥与新楼相连。这个空间建于1928年，最后一次翻修是在20世纪50年代，由于新空间的可用性而被废弃，但如果进行翻新并达到当前的研究实验室标准，它将允许科学家有效的实验室和办公桌空间的显着扩展，并允许进一步招聘。

DESCRIPTION (provided by applicant): In the last decade the Cleveland Clinic Taussig Cancer Institute (TCI) has demonstrated tremendous growth in terms of cancer care, clinical trials and translational cancer research. This expansion was initially enabled by a move into a new building in 2000, of which the 4th floor houses the Cancer Institute research laboratories. Originally, laboratories were administered within the Center for Hematology and Oncology Molecular Therapeutics, but the success in obtaining research funding, new clinical trials with laboratory components and recruitment of translational cancer researchers has led to the formation of the new Department of Translational Hematology and Oncology Research (THOR) headed by Dr. Jaroslaw Maciejewski, the PI of this proposal. Currently, the physical facilities include the laboratories of the PIs, shared equipment areas, a conference room, offices for staff and administration as well as room for hematology/oncology and postdoctoral fellows. Currently, 45 scientists and technicians and 10 support research personnel occupy the available space, the capacity of which has been exhausted. Prior to construction of the new building in 2000, cancer institute researchers occupied laboratories in the adjacent M building of the hospital, now connected via a bridge with the new building. This space, erected in 1928 and last renovated in the 1950s, has been abandoned due to the availability of new space, but if renovated and brought up to current research laboratory standards, it would allow for significant expansion of the effective laboratory and desk space for scientists and allow for further recruitment. Further growth of the TCI and THOR, which includes planned recruitment, has been impeded by a shortage of laboratory space to be assigned to new investigators. Opening a new wet laboratory space in close proximity to the existing laboratories and shared instrumentation core is essential for continuing growth and expansion of this thriving department and would be in the spirit of NIH ARRA initiative. We propose here a major renovation of 3600 sq. ft. of laboratory space to house up to 4 new PIs and a shared instrumentation core, which would effectively free an additional 500 sq. ft. of the existing space for primary bench space. Expansion of THOR research capabilities is essential for the mission of the TCI, which includes provision of the most advanced cancer care, translational research aiming at improving diagnosis and cure rates of cancer, clinical research and education of the next generation of physician scientists. The specific aim of our application is to renovate and adapt currently unusable laboratory space to provide a venue for expansion of the translational cancer research program. The renovation will improve access to the facility, renovate and adapt to current laboratory standards and associated physical facilities and lead to installation of fixed research equipment.