Restructuring Biomedical Sciences--Form and Function: Remodeling of Cooley Labor

描述（由申请人提供）：我们为蒙大拿州立大学（MSU）的库利实验室提出了一个改造计划。库利实验室目前由四层楼和一个地下室组成，效率非常低，没有空气供应，没有集中冷却，没有真空，也没有蒸馏水/反渗透水。他们每年都会因为违反基础设施和过度使用的规定而被博兹曼消防局引用。在这个提案中，我们要求为一个完整的建筑改造项目提供资金，以创建一个新的最先进的设施，将来自不同研究主题的生物医学研究人员聚集在唯一一个安全进入动物资源设施的建筑中。密歇根州立大学的研究发展迅速，密歇根州立大学现在被归类为卡内基一号研究机构。然而，进一步的增长取决于有利于生物医学研究的研究空间的发展。库利实验室的建设计划已经准备就绪，它将改造成一座可持续的现代化建筑，为宿主-病原体相互作用、神经系统疾病和激光物理在生物医学问题上的应用提供新的、有主题组织的研究集群。随着结构和机械系统的全面检修，每个楼层都将定制以满足这些主题需求。在之前的一个项目中，NIH审查并批准了两层楼和相关的基础设施（机械系统，结构），一直到施工文件。这个新项目将利用以前提交的设计，大大缩短了开始施工的时间。我们相信2010年11月开工是可以实现的。该项目计划获得LEED银级认证，并已在USGBC注册。翻新现有设施，而不是新建，不仅符合良好的可持续实践，而且更具成本效益。仅设计和施工就将在蒙大拿州提供129个工作岗位，并将对现有的nih资助的研究项目以及ncrr资助的密歇根州立大学的基础设施赠款（如COBRE和INBRE项目）产生重大影响。

DESCRIPTION (provided by applicant): We propose a program for the renovation of the Cooley Laboratories at Montana State University (MSU). Cooley laboratories currently consist of four floors and a basement that are highly inefficient, with no air supply, centralized cooling, vacuum, or distilled/RO water. They are annually cited by the Bozeman Fire Department for infrastructure and overuse violations. In this proposal, we are requesting funds for a full building renovation program to create a new state-of-the-art facility that will unite biomedical researchers from different departments by research themes in the only building with secure access to the animal resource facility. Research at MSU has grown rapidly, and MSU is now classified as a Carnegie I research institution. However, further growth depends upon the development of research space that is conducive to biomedical research. Shovel-ready construction plans exist to remodel the Cooley Laboratories to produce a sustainable, modern building that will power new, thematically organized, research clusters in host-pathogen interactions, neurological diseases, and application of laser physics to biomedical problems. Along with a complete overhaul of structure and mechanical systems, each floor will be customized to meet these thematic needs. NIH reviewed and approved two floors and associated infrastructure (mechanical systems, structure) in a previous project, all the way through construction documents. This new project will take advantage of the previous design submission and significantly shorten the time to the start of construction. We believe a November 2010 start date for construction is achievable. This project is planned to be LEED certified at a Silver level and has already been registered with USGBC. Renovating an existing facility, rather than building new, is in keeping with good sustainable practice, in addition to being more cost effective. Design and construction alone will account for 129 jobs in the state of Montana, and will have a significant impact on existing NIH-funded research programs as well as NCRR-funded infrastructure grants to MSU such as the COBRE and INBRE programs.