Cardiovascular and Regenerative Sciences in WIMR Phase II

描述(由申请者提供)：该项目是WIMR第二阶段的心血管和再生科学，是威斯康星医学研究所(WIMR)战略倡议的组成部分。WIMR体现了三个阶段的努力，即广泛地将威斯康星大学医学和公共卫生学院(SMPH)的研究事业纳入物质和智力资源，确保将基础和临床科学完全整合到发现和翻译的引擎中，从而促进广泛的疾病驱动倡议的创新和应用。目前的C06提案是WIMR第二阶段项目的子集，该项目是一个耗资1.34亿美元、总面积为266,000平方英尺(GSF)的设施，包括在WIMR第一阶段已完工的基础上建造的七个实验室楼层。WIMR第二阶段的主要科学重点领域是神经科学、心血管科学、再生医学、分子医学和视觉科学研究的整合，以及基础癌症生物学和再生医学在外科专业的应用。这项提议要求提供部分支持，以便在WIMR II中建造和配备一个以心血管和心脏再生科学为重点的研究层。在这项提案中，我们将全面扩建并配备WIMR II的一层，提供超过25,000平方英尺(ASF)的高度一体化空间。正如所展示和讨论的那样，共享基础设施确保了规模经济，并进一步增强了协作。这些资源是专门针对那里的心血管和心脏再生科学的。总而言之，我们建议扩建WIMR二期的一层，并为其配备25,000个ASF，耗资近1900万美元，这项请求为1500万美元。这将在一个高度跨学科的设施中为至少12至15个研究团队提供最先进的设施。

DESCRIPTION (provided by applicant): This project, Cardiovascular and Regenerative Sciences in WIMR Phase II, is an integral component of the Wisconsin Institutes for Medical Research (WIMR) strategic initiative. WIMR embodies a three phase effort to broadly incorporate the research enterprise of the University of Wisconsin School of Medicine and Public Health (SMPH) into a physical and intellectual resource that ensures complete integration of basic and clinical sciences into an engine of discovery and translation, thereby facilitating innovation and application to a broad swath of disease-driven initiatives. The present C06 proposal is a subset of the WIMR Phase II project, a $134M, 266,000 gross square foot (GSF) facility comprised of seven laboratory floors constructed on top of underpinnings already completed during WIMR Phase I. The major scientific focus areas of WIMR II are the integration of neuroscience, cardiovascular science, regenerative medicine, molecular medicine, and visual science research, as well as fundamental cancer biology and regenerative medicine applications in surgical specialties. This proposal requests partial support to construct and fit-out one research floor in WIMR II focused upon cardiovascular and cardioregenerative sciences. In this proposal, we will fully build-out and equip one floor of WIMR II, providing more than 25,000 assignable square feet (ASF) of highly integrated space. As shown and discussed, shared infrastructure ensures economy of scale and further enhances collaboration. These resources are specific to the cardiovascular and cardioregenerative science positioned there. In conclusion, we propose to build-out and equip one floor of WIMR Phase II, with 25,000 ASF, at a cost of nearly $19M, with this request being $15M. This will provide state-of-the-art facilities in a highly transdisciplinary facility for at least 12 to 15 research teams.