Expansion of Animal Resources for Large Animals

杜克大学致力于科学研究及其转化，以改善人类健康，包括在研究中适当使用动物。杜克大学的研究人员目前或过去的研究需要大量使用美国农业部覆盖的物种，他们每年要从美国国立卫生研究院支付20,407,773美元的直接费用。预计到2016年，这些项目的力度将使对大型动物物种的需求增加一倍，而目前的需求已经超过了能力。为了扩大、现代化和集中美国农业部覆盖的物种的住房和程序空间，以满足这些物种当前和未来的研究需求，并使空出的空间能够回填，杜克大学现有的中央Vivarium的两层建筑增加了19,215总平方英尺（gsf）（16,763净平方英尺，效率为87%）。新增的将包括一楼（8,423 nsf）的非人类灵长类动物住房和程序空间，以及二楼（8,340 nsf）的大型动物住房和程序空间。这一增加将允许在这个单一的动物园内整合美国农业部保护的物种，同时促进专业设备的共享并提高安全性。专门为美国农业部覆盖的物种建造，增加的设计将是灵活的，以最大限度地发挥其效用，因为研究需要在未来几年发展。该设计还通过利用现有的笼子清洗、支持和手术设施，最大限度地增加了对研究的影响。毗邻现有的中央兽兽场和外科馆，该扩建项目将无缝地整合到杜克大学实验动物资源部门的兽医、动物护理和行政结构中。扩建计划始于2007年，但由于经济原因于2008年暂停。杜克大学目前已经无法满足非人类灵长类动物、农业动物和犬科动物的教师需求，而这些物种的空间限制也阻碍了对依赖这些模型的教师的招聘。此外，杜克大学的研究人员在神经生物学、运动障碍、外科、移植、心血管疾病、传染病和其他领域取得了有希望的发现和转化进展，但由于中央住房的限制和美国农业部覆盖物种的有限程序空间，他们无法加速转化或扩大他们的研究范围。此外，杜克大学的试管不能支持根据良好实验室规范（GLP）法规进行的研究，限制了研究人员在向食品和药物管理局提交监管档案之前进行内部安全性和毒性研究的能力。由于目前使用的空间设计不理想，使得这些物种的日常饲养、护理和监测效率低下，这些问题更加严重。拟议的项目将纠正这些存在的问题，这样做将加速发现和转化，为基础研究、转化研究和临床前研究提供最先进的空间，并创造近期和长期的就业机会。为了与杜克大学对可持续发展的承诺保持一致，该扩建项目将满足LEED认证的要求。

DESCRIPTION (provided by applicant): Duke University is committed to scientific research and its translation to improve human health, including through appropriate use of animals in research. Duke researchers whose current or past investigations have required significant use of USDA-covered species are responsible for $20,407,773 in annual direct costs from the National Institutes of Health. Strength of these programs is projected to double the need for large animal species by 2016, and current demand already exceeds capacity. To expand, modernize and centralize housing and procedural space for USDA-covered species, to meet current and projected research needs with these species, and to enable backfill of vacated spaces, construction of a two-story addition of 19,215 gross sf (gsf) (16,763 net sf, 87% efficiency), to Duke's existing Central Vivarium is proposed. The addition will include non-human primate housing and procedure space on the first floor (8,423 nsf) and large animal housing and procedure space on the second floor (8,340 nsf).The addition will allow consolidation of USDA-covered species within this single vivarium, while facilitating sharing of specialized equipment and enhancing security. Purpose-built for USDA-covered species, the addition will be designed to be flexible to maximize its usefulness as research needs evolve in coming years. The design also maximizes the addition's impact on research by utilizing existing cagewashing, support and surgical facilities. Contiguous with the existing Central Vivarium and Surgical Pavilion, the addition will be incorporated seamlessly into the veterinary, animal care, and administrative structure of Duke's Division of Laboratory Animal Resources. Planning for this addition was started in 2007 and halted in 2008 due to the economy. Duke already cannot accommodate current faculty needs for non-human primates, agricultural animals, and canines, and space constraints for these species have precluded recruitment of faculty who rely on these models. Furthermore, Duke investigators with promising findings and translational advances in neurobiology, movement disorders, surgery, transplantation, cardiovascular disease, infectious disease, and other fields are unable to accelerate translation or expand the scope of their research due to central housing constraints and limited procedural space for USDA-covered species. In addition, Duke's vivaria cannot support studies conducted under Good Laboratory Practice (GLP) regulations, restricting investigators' ability to conduct safety and toxicity studies in-house prior to submitting regulatory dossiers to the Food and Drug Admin. These problems are exacerbated by suboptimal design of the currently used space that makes routine husbandry, care, and monitoring of these species inefficient. The proposed project will rectify these existing problems, and in doing so will accelerate discovery and translation, provide state-of-the-art space for basic, translational, and pre-clinical studies, and create near-term and long-term jobs. In keeping with Duke's commitment to sustainability, the addition will meet requirements for LEED certification.