Forsyth Expansion for the Center for Discovery at the Host-Biofilm Interface

描述(由申请人提供)：口腔和颅面部疾病研究的世界领先者福赛斯研究所申请379万美元，用于翻新8935平方英尺的空间，用于实验室、核心设施、办公室和临床研究，以创建一个新的跨学科卓越研究中心：宿主-生物膜界面发现中心(CHBI)。该项目代表着该研究所研究计划的显著扩展，并建立在Forsyth在微生物学/分子遗传学、微生物信息学和免疫学方面的国际知名研究计划的基础上。现在已经为建立新的跨学科中心奠定了基础，该中心以口腔为模型系统，专注于一个关键问题：人类如何与微生物乘客共存？CHBI的创建将涉及招募6-8名新的首席研究人员，他们将与我们现有的研究优势相协同，并将在理解人类如何与他们的微生物“乘客”在健康方面共存，以及宿主-生物膜界面的扰动如何导致疾病方面取得巨大的新进展。 一项积极的运动将在以下领域招募新的科学家：人类遗传学/基因组学和蛋白质组学；唾液生物学；微生物-上皮相互作用；免疫系统的个体发育；粘膜表面的调节机制；共生关系的建立；微生物-矿化组织相互作用；以及临床/翻译研究，特别是与糖尿病、代谢综合征、肥胖、心血管疾病、炎症性肠道疾病、早产等口腔-全身疾病相互作用有关的研究。CHBI将酌情进一步纳入新资助的哈佛大学范围内的CTSC(‘CATALYST’，http：calyst.atherard.edu)和哈佛系统生物学中心。Forsyth的资金将受到这一方案扩展的影响：11,666,314美元(40个正在进行的项目)和55个(55)未决项目(17,194,158美元)。据我们所知，CHBI在口腔健康领域将是独一无二的，并将使Forsyth将其在该领域的长期领导地位提升到一个新的水平。 这项申请的背景是Forsyth将于2010年初夏将其目前的业务搬迁到位于马萨诸塞州剑桥肯德尔广场地区的一个新的最先进的设施。该研究所将租赁至少15年的空间(另外还有两个5年的选择)，从而保证翻修后的空间长期占用。由于Forsyth现有的项目搬迁本身将独立于ARRA建设拨款资金而发生，因此本申请仅请求为创建CHBI的项目扩展的空间的翻新提供支持。这项计划的扩展已经“准备就绪”，必须在2010年初夏之前完成。它将涉及为美国创造大量就业机会。这包括直接的就业影响(建筑和设备制造，15-17个美国工作岗位)，以及更长期的可持续就业：6-8名首席科学家和大约18-24名技术人员，包括博士后研究员和实验室技术员。因此，如果这项申请获得资金，将为美国创造39-49个新的就业机会。

DESCRIPTION (provided by applicant): The Forsyth Institute, the world's leader in oral and craniofacial disease research, requests $3.79 million to renovate 8,935 ft2 of space for laboratory, core facility, office and clinical research use to create a new interdisciplinary research center of excellence: the Center for Discovery at the Host -Biofilm Interface (CHBI). This project represents a significant expansion of the Institute's research programs, and builds upon Forsyth's internationally-renowned research programs in microbiology/molecular genetics, microbial informatics and immunology. The stage is now set for new paradigm-setting interdisciplinary center that uses the oral cavity as a model system to focus on a critical question: how do humans co-exist with their microbial passengers? The creation of the CHBI will involve the recruitment of 6-8 new principal investigators who will synergize with our existing research strengths, and will generate dramatic new advances in understanding how humans co-exist with their microbial 'passengers' in health, and how perturbations at the host-biofilm interface lead to disease. An aggressive campaign will recruit new scientists in the following areas: human genetics/genomics and proteomics; salivary biology; microbial-epithelial interactions; ontogeny of the immune system; regulatory mechanisms at mucosal surfaces; establishment of commensalism; microbial-mineralized tissue interactions; and clinical/translational research particularly relating to oral-systemic disease interactions in diabetes, metabolic syndrome, obesity, cardiovascular disease, inflammatory bowel diseases, premature birth, and others. The CHBI will be further integrated as appropriate into the newly funded Harvard-wide CTSC ('CATALYST', http:catalyst.harvard.edu), and the Harvard Center for Systems Biology. The funding at Forsyth that will be impacted by this programmatic expansion is: $11,666,314 (40 active projects), and fifty-five (55) pending projects ($17,194,158). To our knowledge, the CHBI will be unique in the field of oral health, and will allow Forsyth to bring its long leadership in this field to a new level. The background to this application is that Forsyth will be relocating its present operation to a new state-of the art facility in the Kendall Square area of Cambridge MA, in early Summer 2010. The Institute will lease space for a minimum of15 years (with two additional 5 year options), thus guaranteeing long term occupancy of renovated space. Because Forsyth's existing program relocation per se will occur independent of ARRA construction grant funding, this application requests support only for renovation of space for program expansion for the creation of the CHBI. This program expansion is 'shovel ready' and must be completed by early Summer 2010. It will involve substantial U.S. job creation. This includes immediate job impact (construction and equipment manufacture, 15-17 U.S. jobs), and substantially more long term sustainable employment: 6-8 principal scientists and approximately 18-24 technical personnel including post-doctoral fellows and laboratory technicians. Accordingly, 39-49 new U.S. jobs will be created should this application be funded.