BSL-3/ABSL-3 Expansion for Select Agent Translational Research

描述（由申请人提供）：路易斯维尔大学提议扩大现有的预测医学中心（CPM）区域生物控制实验室（RBL），以支持在长期疗效/产品评估研究中使用啮齿动物，兔子和雪貂作为动物模型的选择剂的工作。此次扩张将促进转化研究，增加血液学、临床和全动物成像服务以及疗效/产品评估的相关服务。此外，在动物研究转移到ABSL3之前，扩建将为ABSL2提供接收、检疫和疫苗接种空间。ABSL2/3动物饲养区和BSL3支持实验室将开发为具有共享程序和检查空间的套房。这些套件将利用CPM现有的三模态活体动物成像能力和其他现有的支持服务。重要的是，扩建将为使用Provantis（tm）系统或其他类似类型的经过验证的监测系统进行GLP研究提供基础设施。现有的RBL设计和建造的基础设施将很容易适应未来的增长。现有的公用设施（电力、卫生下水道、雨水下水道、供水服务、消防服务、应急电源）的大小和安装是为了适应扩建。现有CPM内现有的动物笼和架清洗和灭菌设备可以容纳这一额外的能力。安全基础设施（内部设施和现场围栏，挫折和入侵屏障）装货码头和服务区将被安装。所有这些都足以扩大容量。扩建的场地容量也被容纳，现有设施的设计达到了LEED认证。这将使扩建项目也能获得LEED认证，并与路易斯维尔大学提出的其他可持续发展倡议保持一致。

DESCRIPTION (provided by applicant): The University of Louisville proposes to expand the existing Center for Predictive Medicine (CPM) Regional Biocontainment Laboratory (RBL) to support work with select agents utilizing rodents, rabbits and ferrets as animal models in long term efficacy/product evaluation studies. The expansion will facilitate translational studies with the addition of hematology, clinical and whole-animal imaging services and related services for efficacy/product evaluation. Further, the expansion will provide receiving, quarantine and vaccination space in ABSL2 prior to animal studies transfer to ABSL3. ABSL2/3 animal holding areas and BSL3 support labs will be developed as suites with shared procedure and exam spaces. These suites will take advantage of existing trimodal live animal imaging capacities within the CPM and other existing support services. Importantly, the expansion will provide infrastructure for GLP studies with the Provantis(tm) system or other similar types of validated monitoring systems. The existing RBL was designed and built with infrastructure that will easily accommodate this future growth. Existing utilities (electrical, sanitary sewer, storm sewer, water service, fire service, emergency power) are sized and installed to accommodate expansion. Existing animal cage and rack wash and sterilization equipment within the existing CPM can accommodate this additional capacity. Security infrastructure (internal to facility and site fencing, setbacks and intrusion barriers) loading dock and service areas will be installed. All are adequate for expanded capacity. Site capacity for expansion is also accommodated and the existing facility is designed to attain LEED certification. This will permit the expansion to also achieve LEED certification and be in step with other sustainability initiatives set forth by the University of Louisville.