FACILITIES IMPROVEMENT FOR INFECTIOUS DISEASE RESEARCH

描述（由申请人提供）： 本C 06研究设施建设提案旨在更新研究设施，以加强一批使用综合模型阐明人类传染病基本细胞机制的紧密结合的研究人员。最近资助的项目补助金（PPG）和最近在传染病研究领域的教师招聘计划有必要改善研究设施的需要。翻新后的研究设施将使参与PPG的研究实验室得以合并和完全整合，解决基础设施不足的问题，并为更多的研究人员腾出研究空间。拟议的翻修是改善学院基础设施和满足传染病研究未来需求的总体目标的一部分。设施翻新将通过戈斯实验室内8,776平方英尺的空间翻新，加强公共卫生系统支持的生物医学研究的开展。这个空间目前包含未占用的无特定病原体的猫群住房，一个相邻的研究实验室，gnotobiotic生命实验室和一个过时的尸检设施。该空间将进行翻新，以创建4个宽敞的现代化研究实验室和支持空间，以及一个专门的啮齿动物表型和感染性尸检实验室。所有研究实验室，以及啮齿动物表型分析、感染性尸检和致菌衍生实验室，均设计为与公共领域充分隔离，并具有受控访问。该设施的总体目标是促进聚集在其围墙内的调查人员之间的互动，同时提供有效的传染病控制和安全。该项目拥有出色的机构支持和强大的行政结构，以确保建设项目的成功和提高公共卫生支助研究的研究生产力。

DESCRIPTION (provided by applicant): This C06 research facilities construction proposal seeks to renovate research facilities to enhance a group of well-bonded investigators that use integrated models to elucidate basic cellular mechanisms of human infectious disease. The recent funding of a program of projects grant (PPG) and recent faculty hires in the area of infectious disease research has necessitated the need for improved research facilities. The renovated research facilities will permit the consolidation and complete integration of the research laboratories involved in the PPG, address infrastructure deficits, and produce vacated research space for additional investigators. The proposed renovations are part of an overall goal to improve the infrastructure of the College and to meet future needs in infectious disease research. The facilities renovations will enhance the conduct of PHS-supported biomedical research through the renovation of 8,776 square feet of space within Goss Laboratories. This space currently contains unoccupied specific pathogen-free cat colony housing, an adjacent research laboratory, gnotobiotic life laboratory, and an outdated necropsy facility. This space will be renovated to create 4 spacious and modem research laboratories and support space, as well as a dedicated rodent phenotyping and infectious necropsy laboratory. All research laboratories, as well as the rodent phenotyping, infectious necropsy, and gnotobiotic derivation laboratories are designed to be sufficiently isolated from the public realm and have controlled access. An overall goal of the facility is to foster interaction among the investigators that are being brought together within its walls, while providing effective infectious disease control and security. The project has outstanding institutional support and a strong administrative structure to ensure success of the construction project and enhancement of research productivity of PHS-supported research.