CARDIAC ENERGY METABOLISM IN HEART FAILURE

心力衰竭的治疗在美国仍然是一个主要的经济和临床问题。心脏衰竭不能有效地将食物燃烧的化学能转化为收缩功的机械能。代谢功能障碍对心力衰竭的影响还知之甚少。越来越多的证据表明，能量代谢受损会导致心力衰竭时的收缩功能障碍和进行性左心室重构。此外，有人提出代谢疗法可能在改善心功能和减缓心力衰竭的临床进展方面有效。 为2006年9月6-9日在华盛顿州塞米阿穆奥举行的题为“心力衰竭中的心脏能量代谢：从概念到治疗”的会议请求支持。本次会议的目的是将对心力衰竭和心脏代谢有共同兴趣的不同学科的研究人员聚集在一起，介绍该领域的最新研究，并集中讨论心力衰竭的代谢缺陷以及各种代谢治疗的可能性。将有来自美国、加拿大、欧洲和非洲的30名受邀演讲者，预计还会有70到90名注册者。该计划由五个研讨会组成，涵盖基础研究、翻译研究和临床研究。每个专题讨论会将由受邀发言者和提交的摘要的口头陈述组成。提交的摘要还将在海报会议上展示，并将有充足的时间进行正式和非正式的科学讨论。请拨资金用于美国特邀演讲者的支持旅费和会议费用、印刷计划，以及美国研究生和博士后研究员的旅费奖励。这次会议是由心脏和血管代谢学会组织的，这是一家非营利性教育公司，在组织与新陈代谢和心脏病相关的成功会议方面有着既定的记录。

Treatment of heart failure remains a major ecomonic and clinical problem in the US. The failing heart can not effectively transfer the chemical energy from the combustion of foodstuffs to the mechanical energy of contractile work. The consequences of metabolic dysfunction in heart failure are poorly understood. There is increasing evidence that impaired energy metabolism contributes to contractile dysfunction and progressive left ventricular remodeling in heart failure. Furthermore, it has been proposed that metabolic therapies might be effective in improving cardiac function and slowing the clinical progression of heart failure. Support is requested for a meeting entitled "CARDIAC ENERGY METABOLISM IN HEART FAILURE: FROM CONCEPTS TO THERAPIES" in Semiahmoo, Washington, on September 6-9, 2006. The goal of this meeting is to bring together researchers from diverse disciplines with a common interest in heart failure and cardiac metabolism to present the latest research in the field, and to have focused discussions on the metabolic defects in heart failure, and the potential for various metabolic therapies. There will be 30 invited speakers from the US, Canada, Europe and Africa, and an additional 70 to 90 registrants are expected. The program is comprised of five symposia that cover basic, translational, and clinical research. Each symposium will be comprised of a mixture of invited speakers and oral presentations of submitted abstracts. Submitted abstracts will also be presented in poster sessions, and there will be ample time for formal and informal scientific discussion. Funds are requested for support travel and meeting costs for invited speakers from the US, printing of the program, and for travel awards for US graduate students and postdoctoral fellows. The meeting is organized by the Society for Heart and Vascular Metabolism, a not-for-profit educational corporation with an established record for organizing successful meetings related to metabolism and heart disease.