TGF-Beta Superfamily: Signaling and Development

描述（由申请人提供）：转化生长因子- β (tgf - β)超家族是一个在人类发育和健康中起重要作用的分泌蛋白大家族。tgf - β信号成分的种系突变已被证明有助于血管异常，遗传性出血性毛细血管扩张I型和II型，以及遗传性癌症易感性综合征，幼年型大肠杆菌息肉病。获得性tgf - β信号的改变与许多疾病有关，包括炎症和免疫疾病、心血管疾病和癌症。发育生物学、分子生物学、细胞生物学和生物化学之间的密切相互作用极大地促进了tgf - β家族活动信号通路的鉴定。在提议的会议中，组织者将利用这些互动，并继续促进和促进在tgf - β家族生物学各个领域工作的科学家之间的进一步互动。会议的主题将集中在整个tgf - β超家族的发育生物学和生物化学上，并描述这些过程与人类疾病的关系。会议将包括八次全体会议，每次会议有四名发言人，一次特别会议专门由新调查人员进行简短的会谈，以及两次海报会议。下午将自由地观察海报，并鼓励调查人员之间的非正式互动。这将是由美国实验生物学学会联合会（FASEB）主办的第三届两年一次的同名会议，会议将于2005年6月25日至30日在科罗拉多州斯诺马斯举行。根据以往会议的出席情况和与会者的反馈，组织者预计这次会议将继续成功地联合对tgf - β生物学各个方面感兴趣的研究人员。

DESCRIPTION (provided by applicant): The transforming growth factor-beta (TGF-beta) superfamily is a large family of secreted proteins that play important roles in human development and health. Germline mutations in TGF-beta signaling components have been shown to contribute to the vascular abnormality hereditary hemorrhagic telangiectasia type I and type II, and to the hereditary cancer predisposition syndrome juvenile polyposis coli. Acquired alterations in TGF-beta signaling contribute to numerous diseases, including inflammatory and immune diseases, cardiovascular disease, and cancer. Identification of the signaling pathways involved in TGF-beta family actions was greatly facilitated by the close interplay among developmental, molecular, cellular biology, and biochemistry. In the proposed conference, the organizers will draw on those interactions and continue to facilitate and foster further interactions among scientists working in various areas of TGF-beta family biology. The topics at the conference will focus on the developmental biology and biochemistry of the entire TGF-beta superfamily, and delineate how these processes relate to human disease. The conference will include eight plenary sessions with four speakers each session, a special session devoted to shorter talks by new investigators, and two poster sessions. Afternoons will be left free to observe posters and encourage informal interactions among investigators. This will be the 3rd biennial conference of the same title hosted by the Federation of American Societies of Experimental Biology (FASEB), and will be held in Snowmass, Colorado from 25 to 30, June 2005. Based on attendance at previous conferences and feedback from attendees, the organizers anticipate that this version will continue to be a success in uniting investigators interested in the various aspects of TGF-beta biology.