FASEB Conference-Mechanism and Regulation of Prokaryotic Transcription

描述（由申请人提供）：本提案要求部分支持将于2005年6月18日至25日在佛蒙特州萨克顿河举行的FASEB关于Proximate转录机制和调控的会议。 这个会议总是订满了人。这次非常成功的会议是唯一一次广泛考虑原核转录的会议。其独特的跨学科性质汇集了相关但通常不交叉领域的前沿研究，从而促进了思想的交叉。正是在这里，新的结构被揭开，单分子研究被展示，转录电路的模型被提出。在本次会议上，我们继续强调单分子研究，并增加了对转录控制的新兴系统生物学方法的讨论。会议的建议部分是：RNA聚合酶的结构和功能，II-III。转录起始; IV-V.转录延长/终止; VI.抑制剂/激活剂; VII.全球监管网络; Vim。压力和发展的调节; IX。监管战略。每场会议既有特邀发言者，也有从摘要中选出的发言者。我们邀请的演讲者包括妇女，少数民族和新教师。参与者主要来自主要研究机构，代表来自小型学院和行业，包括教师，博士后研究员和研究生。 国家一级的研究已经确定，需要将纳米技术和系统生物学方法与审查生物学问题的其他方法结合起来。这次会议就是这样做的。人们使用每一种可能的方法来解决一个易处理的重要生物学问题-原核生物转录的机制和调控-将在很长一段时间内进行密切的互动。其结果将不仅是所有这些办法日益综合。这也是唯一一个希望进入这一领域的物理学家或建模者可以获得合作者和历史视角的会议。这一活动将产生远远超出本次会议范围的全国性影响

DESCRIPTION (provided by applicant): This proposal requests partial support for a FASEB conference on The Mechanism and Regulation of Prokaryotic Transcription to be held from June 18-25, 2005 at Saxtons River, VT. This meeting is always oversubscribed. This extraordinarily successful meeting is the only one that broadly considers prokaryotic transcription. Its unique interdisciplinary character brings together cutting edge research from related but often non-intersecting field's thereby promoting cross-fertilization of ideas. It is here that new structures are unveiled, single molecule studies are showcased and models of transcriptional circuits are presented. In the current meeting, we continue the emphasis on single molecule studies and increase the discussion of emerging systems biology approaches to transcriptional control. The proposed sessions for the meeting are: Structure and Function of RNA polymerase, ll-lll. Transcription Initiation; IV-V. Transcription elongation/termination; VI. Repressers/Activators; VII. Global Regulatory networks; VIM. Regulation in stress and development; IX. Regulatory strategies. Each session has both invited speakers and those chosen from the abstracts. Our invited speakers include women, minorities and new faculty. Participants are primarily from major research institutions, with representation from small colleges and industry and include faculty, post-doctoral fellows and graduate students. Studies at the national level have identified the need to integrate nanotechnology and systems biological approaches with other methodology for examining biological problems. This meeting does just that. People using every possible approach to a tractable and important biological problem-the mechanism and regulation of prokaryotic transcription - will be interacting intensively for an extended period of time. The outcome will not only be an increasing synthesis of all of these approaches. It is also the only meeting where physicists or modelers wishing to enter this field can gain both collaborators and a historical perspective. This activity will have a national impact far beyond the scope of this meeting