18th North American Testis Workshop

简介（申请人提供）：第十八届北美睾丸研讨会将于2005年3月30日至4月2日在美国华盛顿州西雅图举行。会议的主题是睾丸细胞动力学和内分泌信号。会议的主题和内容将与2003年研讨会的基因组学和蛋白质组学方向形成互补对比。正如上次会议所述，新的分析方法首次揭示了在男性生殖系统中发现的许多基因和基因产物，创造了大量的功能理解积压。目前的挑战仍然是确定这些较大的蛋白质是如何在睾丸、精子生产和雄激素合成中发挥主要生理作用的。2005年研讨会汇集了一批具有独特资格的演讲者，他们向与会者介绍了过去两年该领域的进展。研讨会将分为六个部分：遗传学、发育、内分泌轴、类固醇发生、精子发生和临床相关。遗传学将由杰克逊实验室的伊娃·艾歇尔博士发表主题演讲。利用小鼠遗传学，她将切断Y染色体性别决定区域（Sry）下游效应物的复杂性，并阐明基因组如何编码雄性身体计划。随后的会议将转向内分泌信号和睾丸生殖细胞和体细胞之间的旁分泌串扰。最后一节是关于临床相关性的，旨在从三个角度探讨药物干预治疗不孕症和男性避孕药发展的潜在目标。除了关于受精和精子趋化性的讲座，我们还将邀请约翰霍普金斯大学的Jon Jarrow博士介绍人类睾丸中雄激素微环境的数据。人类睾丸雄激素代谢的独特差异可能对我们理解男性精子发生是如何调节的有着深远的影响。

DESCRIPTION (provided by applicant): The XVIII North American Testes Workshop will be held in Seattle, Washington, on March 30th through April 2nd, 2005. The title theme for the meeting is Testicular Cell Dynamics and Endocrine Signaling. The theme and content of the meeting will make for a complementary contrast to the genomic and proteomic orientation of the previous Workshop of 2003. As was described at the previous meeting, the new profiling methodologies revealed many genes and gene products that were identified in the male reproductive system for the first time, creating an immense backlog of functional understanding. The challenge remained to determine how the larger cast of proteins subserves the main physiological roles of the testes, sperm production and androgen synthesis. The 2005 Workshop assembles a roster of speakers who are uniquely qualified to educate the attendees on advances in the field over the last two years. The Workshop will be organized into six sessions: genetics, development, the endocrine axis, steroidogenesis, spermatogenesis, and clinical correlates. Genetics will be represented in the keynote delivered by Dr. Eva Eicher of the Jackson Laboratory. Using mouse genetics, she will cut through the complexity of the downstream effectors of the sex-determining region of the Y chromosome (Sry), and clarify how the male body plan is encoded by the genome. The subsequent sessions will turn to endocrine signaling and paracrine cross talk between the germ and somatic cells of the testes. The final session on clinical correlates is intended to bring three perspectives on potential targets for drug intervention in the treatment of infertility and male contraceptive development. In addition to talks on fertilization and sperm chemotaxis, we will have Dr. Jon Jarrow of Johns Hopkins presenting data on the androgen microenvironment in the human testes. Differences in androgen metabolism unique to the human testes may have profound implications for our understanding of how spermatogenesis is regulated in men.