Composition, Properties and structure of Tooth Enamel

描述(申请人提供)：本R13申请的目的是请求支持第七届牙釉质组成、性质和基本结构国际研讨会。拟议的研讨会将提供一个国际论坛，在有利于公开、批判性和建设性辩论的环境中介绍牙釉质研究的最新进展。研讨会将于2005年4月10日至14日在马萨诸塞州布鲁斯特的海洋边缘度假村和高尔夫俱乐部举行。牙釉质国际研讨会于1964年在伦敦召开，并于1997年在加利福尼亚州的箭头湖举行，是一次成功的牙釉质国际研讨会。具体地说，拟议的研讨会旨在：1)批评自1997年举行的上一次研讨会以来在牙釉质研究方面取得的重大进展；2)促进更好地了解牙釉质的特性及其在体内形成和破坏的机制；3)激发新的想法，这些想法可能成为开发修复和/或再生牙釉质组织的新的仿生方法的基础，以及防止牙釉质腐烂的方案；以及4)鼓励新的研究人员、少数族裔、妇女和残疾人参与不断增长的研究领域。拟议的研讨会最终将对加强这些领域的研究活动产生重大影响，并导致口腔健康的改善。研讨会将限制为100人参加，以最大限度地发挥互动和关键讨论的作用。与前面的六次专题讨论会一样，专题讨论会论文集(包括同行评议的文章和讨论)将在一个特别期刊版上发表。可能的主题包括：成釉细胞生物学；无机阶段；釉质矿化；成釉细胞基因产品；发育缺陷；进化和系统发育方面；以及仿生学/组织工程。鉴于自上一次牙釉质研讨会以来，在基质介导的釉质形成机制和釉质疾病(如龋齿)方面取得的重大进展，拟议的研讨会是及时的。计划采用独特的方案形式，包括海报和简短的口头陈述，然后在10次专题会议内组织小组讨论，以及两次主旨陈述。建议作出具体努力，促进纳入新的、少数群体和女性调查人员以及残疾人。

DESCRIPTION (provided by applicant): The purpose of this R13 application is to request support for the Seventh International Symposium on the Composition, Properties and Fundamental Structure of Tooth Enamel. The proposed Symposium will provide an international forum for the presentation of the latest advances in dental enamel research within an environment conducive to open, critical and constructive debate. The Symposium will be held on April 10 - 14, 2005 at the Ocean Edge Resort and Golf Club in Brewster, Massachusetts. The "Enamel VII" Symposium builds upon a successful series of international symposia on tooth enamel that began in London in 1964, and last held at Lake Arrowhead, California in 1997. Specifically, the proposed Symposium is designed to: 1) critically address significant advances in enamel research that have taken place since the last symposium was held in 1997; 2) to promote a better understanding of the properties of tooth enamel and mechanisms of its formation and destruction in vivo; 3) to stimulate new ideas that may potentially serve as the basis for the development of novel biomimetic approaches for the repair and/or regeneration of the enamel tissue, as well as protocols for the prevention of enamel decay; and 4) to encourage the involvement of new investigators, minorities, women, and persons with disabilities in the growing area of research. The proposed Symposium should ultimately have a significant impact on enhancing research activities in these areas and lead to an improvement in oral health. The Symposium will be limited to 100 participants to maximize interactions and critical discussions. As with the six preceding symposia, the Proceedings of the Symposium (including peer-reviewed articles and discussions) will be published in a special journal edition. Probable session topics include: Ameloblast Cell Biology; The Inorganic Phase; Enamel Mineralization; Ameloblast Gene Products; Defects of Development; Evolutionary and Phylogenetic Aspects; and Biomimetics/Tissue Engineering. Given the significant advances that have occurred since the last Enamel symposium in these areas, as related to the mechanisms of matrix-mediated enamel formation and enamel disease (e.g. dental caries), the proposed Symposium is timely. A unique program format is planned, consisting of poster and brief oral presentations, followed by panel discussions, organized within 10 thematic sessions, along with two keynote presentations. Specific efforts are proposed to promote the inclusion of new, minority and female investigators, as well as persons with disabilities.