8th International Symposium - Saga of the Genus Bordetella, 1906-2006

百日咳杆菌(当时称为百日咳嗜血杆菌) 1906年，由Bordet和Gengou首次在 巴斯德研究所，该提案中描述的会议将包括 庆祝这一重要事件的百年纪念。其他较早的 属的成员为支气管败血杆菌和副咯血杆菌。 分别于1912年和1938年被孤立。百日咳的发病率是， 然而，现在美国和世界其他地区的增长，尽管 覆盖面广的主动免疫规划。例如， 2003年，美国报告的病例数量接近12000例， 自1980年以来增加了6倍，据报道有18,957例 美国疾病控制与预防中心于2004年宣布。这至少在一定程度上可以归因于 青少年和成人百日咳的认识和发生。 除了最初的波尔德特拉菌外，B.avium是导致 在鸟类中引起呼吸道感染，并导致巨大的 家禽业的经济损失。此外，还有几个新物种 在该属内，如B.hinzii、B.holmesii、B.trematum和B.Petrii， 在疾病谱、致病力方面没有很好的特征 因素或致病因素。百日咳杆菌、副百日咳杆菌、 已经对支气管败血杆菌和禽类杆菌进行了测序，数据 出版了。 这项提案要求为学生和博士后提供支持 出席第八届国际研讨会：属的传奇 波尔德泰拉，将于2006年11月在巴黎巴斯德研究所举行。 波德泰拉社区是一个特别开放和合作的社区 科学家的集合，重要的是保证和支持 受训人员出席这样的会议。

Bordetella pertussis (at that time called Haemophilus pertussis) was cultured for the first time in 1906, by Bordet and Gengou, at the Institute Pasteur, and the meeting described in this proposal will include celebration of the centennial for that important event. Other early members of the genus, B. bronchiseptica and B. parapertussis, were isolated in 1912 and 1938, respectively. The incidence of pertussis is, however, now increasing in the US and other parts of the world, despite active immunization programs with wide coverage. For example, the number of reported cases in the US was almost 12,000 in 2003, an increase of six-fold since 1980 and there were 18,957 cases reported to the CDC in 2004. This is attributable, at least in part, to increases in recognition and occurrence of adolescent and adult pertussis. Beyond the original bordetellae, B. avium is an important cause of respiratory infections in birds and is responsible for tremendous economic losses for the poultry industry. In addition, several new species within the genus, such as B. hinzii, B. holmesii, B. trematum and B. petrii, are not well characterized with regard to spectrum of disease, virulence factors or pathogenesis. The genomes for B. pertussis, B. parapertussis, B. bronchiseptica and B. avium have been sequenced and the data published. This proposal is requesting support for students and post-doctoral fellows to attend the Eighth International Symposium: Saga of the Genus Bordetella, to be held in November 2006 at the Institute Pasteur, Paris. The bordetella community is an especially open and collaborative collection of scientists and it is important to assure and support attendance of trainees at meetings such as this.