Seventh International Symposium on Pertussis

描述（由申请人提供）：百日咳仍然是全球范围内的一个重大健康问题，每年造成近50万人死亡。在美国，通过接种疫苗，这种疾病得到了控制，但没有被消灭，但疫苗改进的领域已经确定。 第七届国际百日咳研讨会：基因组、发病机制和免疫将于2002年9月18日至22日在英国剑桥举行。目标参与者包括百日咳领域的研究人员，特别强调对百日咳博德特氏菌的发病机制和免疫反应的基本机制，但将向任何感兴趣的方面开放。预计将有200至300名科学家、临床医生、疫苗制造商以及公共卫生和监管官员出席。会议的目标是介绍前沿研究，促进新思想的综合。将涵盖的主题包括：更新了已知和潜在的毒力因子（粘附和毒素），毒力因子表达的调节，来自博德特氏菌基因组的信息，宿主基因表达的微阵列分析，流行病学研究和临床试验的经验教训，免疫反应和人类发病机制的其他研究。在最后一节中，我们将尝试建立一个统一的百日咳发病机制模型。为了鼓励参与，我们将使用交互式海报格式。在整个会议期间，与会者都可以在讨论中的问题的示意图上写字，提出他们希望得到解决的见解或问题。该领域的专家将总结海报并得出总体结论。这次会议将导致对这种生物体的生物学有更深入的科学了解，并有望开发出更有效的方法来控制这种疾病。

DESCRIPTION (provided by applicant): Whooping cough remains a significant health problem worldwide causing nearly half a million deaths a year. This disease has been controlled, but not eliminated, by vaccination in the U.S., but areas for vaccine improvement have been identified. The Seventh International Symposium on Pertussis: Genome, Pathogenesis and Immunity will be held 18th thru 22nd of September, 2002, in Cambridge England. Targeted participants include researchers in the field of pertussis with a special emphasis on basic mechanisms of Pathogenesis and immune responses to Bordetella pertussis but will be open to any interested party. Anticipated attendance is 200 to 300 scientists, clinicians, vaccine maufacturers, and public health and regulatory officials. The goals of the meeting are to present cutting-edge research and promote synthesis of new ideas. Topics to be covered include: Updated information on known and potential virulence factors (adhesions and toxins), Regulation of virulence factor expression, Information from the Bordetella genomes, Microarray analysis of host gene expression, Lessons from epidemiologic studies and clinical trials, Immunologic responses, and other investigations of pathogensis in humans. In the last session, we will attempt to develop a consolidated model of pertusis pathogenesis. To encourage participation we will use an interactive poster format. Posters with a diagrammatic outline of the problems under discussion will be available throughout the meeting for participants to write on, offering both insights or questions they hope will be addressed. Experts in the area will summarize the poster and draw overall conclusions. This meeting will lead to a greater scientific understanding of the biology of this organism, and the promise for developing a more effective means to control this disease.