2006 Biophysical Discussions - Molecuar Motors: Point Counterpoint

描述（由申请人提供）：2006年生物物理学会讨论，题为“分子运动-点对位”，致力于对我们对这些多样化和病理生理相关的酶机制的知识现状进行批判性评估，讨论将有助于解决有关运动功能的悬而未决的问题，并导致有关未来方向的新想法的发展。会议将于2006年10月19日至22日在加利福尼亚州的阿西洛马举行。尽管近年来这一领域取得了迅速的进展，但仍存在一些重大问题尚未解决。是否所有的电机都有不同的电机超家族所共有的共同结构元件？如果是这样的话，这告诉我们构造一个马达需要什么？不同的马达是如何将ATP水解的能量转化为力和运动的？它们是否都使用了相似的机制？马达如何决定它们的运动方向，又是如何调节它们的？结构和酶在体外的研究能告诉我们运动是如何在细胞中起作用的，反之亦然。从分子结构到单分子力学，再到分子遗传学和细胞生物学，来自不同领域的演讲者和参与者将在论坛上进行互动，旨在批判性地评估我们的知识状况，并就该领域未来的研究方向提出新的想法。当我们认识到分子马达在从癌症到动脉粥样硬化、肌萎缩侧索硬化症到阿尔茨海默病等一系列疾病的病理生理学中所起的核心作用时，解决这些尚未解决的问题已成为一个特别紧迫的问题。

DESCRIPTION (provided by applicant): The 2006 Biophysical Society Discussions, entitled "Molecular Motors-Point Counterpoint", is devoted to a critical evaluation of the current state of our knowledge about these diverse and pathophysiologically-relevant enzymatic machines-a discussion that will help resolve outstanding questions regarding motor function and lead to the development of new ideas about future directions. It will be held in Asilomar, California, from October 19-22, 2006. Although this field has made rapid progress in recent years, major unresolved questions remain. Do all motors have common structural elements that are shared by distinct motor superfamilies? If so, what does this tell us about what it takes to construct a motor? How do different motors convert the energy of ATP hydrolysis into force and movement, and are similar mechanisms used by all of these? How do motors determine their direction of movement, and how are they regulated? What can structural and enzymatic studies in vitro tell us about how a motor functions in the cell, and vice versa. A diverse group of speakers and participants with a broad range of expertise from molecular structure to single molecule mechanics to molecular genetics and cell biology will interact in a forum designed to critically evaluate our state of knowledge and develop new ideas regarding the future direction of research efforts in this field. Addressing these unresolved issues has become a particularly pressing concern as we have come to appreciate the central role that molecular motors play in the pathophysiology of a wide range of diseases-from cancer to atherosclerosis to amyotrophic lateral sclerosis to Alzheimer's disease.