Biofilm-Material Interactions-New Tools, Technologies, and Opportunities

描述（由申请人提供）：植入生物医学设备和组织表面的细菌感染对人类健康构成了日益严重的威胁，具有重大的临床和经济后果。在许多感染中，细菌附着在医疗设备或受损组织的表面，随后发展成高度合作的群落，称为生物膜。生物膜中的细菌很好地保护了宿主防御和抗生素，几乎所有这些都是为了对抗浮游状态的细菌而开发的。缺乏替代策略，感染的生物医学设备，从导管到骨科植入物，都被简单地移除。特别是对于嵌入式设备，这样的操作会极大地影响后续翻修手术的成功，使患者产生广泛的不适，并导致医疗保健成本迅速上升。解决这个复杂问题的技术部分在于：(1)利用纳米技术的最新和未来进展，开发多功能表面，以抵抗生物膜的形成，减少感染的发生率，同时促进健康组织的粘附；(2)提高高通量体外工具的预测能力，以模拟生物膜生理学并量化生物膜对候选治疗策略的反应，从而促进将有前途的实验室概念快速安全地转化为临床实践。本次研讨会的一个关键目标是提供一个论坛来评估，从广泛不同的跨学科的角度，如何纳米技术，微反应器系统，表面化学和现代微生物学的概念可以整合和利用，以彻底改变我们研究和应对生物膜相关传染病的方式在未来十年。

DESCRIPTION (provided by applicant): Bacterial infections of implanted biomedical devices and tissue surfaces constitute an ever-increasing threat to human health with significant clinical and economic consequences. In many infections, bacteria attach to the surfaces of medical devices or compromised tissue and subsequently develop into highly cooperative communities known as biofilms. Bacteria in a biofilm are well protected from host defenses and antibiotics, almost all of which have been developed to combat bacteria in their planktonic state. Lacking alternative strategies, infected biomedical devices ranging from catheters to orthopedic implants are simply removed. Particularly for in-dwelling devices, such a procedure can substantially compromise the success of a subsequent revision surgery, produce extensive patient discomfort, and lead to rapidly escalating health-care costs. A technology part of a solution to this complex problem resides in: (1) the exploitation of recent and future advances in nanotechnology to develop multifunctional surfaces which resist biofilm formation and reduce the incidence of infection while promoting the adhesion of healthy tissue, and (2) increasing the predictive capability of high-throughput in vitro tools to emulate biofilm physiology and quantify biofilm responses to candidate treatment strategies in order to facilitate rapid and safe translation of promising laboratory concepts into clinical practice. A key goal of this symposium is to provide a forum to assess, from widely varying interdisciplinary perspectives, how nanotechnology, microreactor systems, surface chemistry, and modern concepts of microbiology can be integrated and exploited to revolutionize the way we both study and respond to biofilm-associated infectious diseases over the coming decade.