Liver Biology /Development /Disease FASEB Conference

描述（由申请人提供）： 目前的申请寻求美国实验生物学学会联合会（FASEB）夏季研究会议“肝脏生物学，发育和疾病”的部分支持。在过去的16年里，该会议每半年举行一次，现在被公认为世界上最重要的会议，涵盖涉及肝脏的基础科学研究的各个方面。会议将于2006年7月22日至27日在科罗拉多的斯诺马斯举行。会议的主要目标是i）整合肝脏生物学不同领域的研究进展，以促进国家和国际范围内的新合作项目，ii）鼓励初级研究人员和女科学家从事肝脏研究，以确保肝脏疾病和生物学研究保持活力; iii）通过基础和临床研究人员的互动，加速将肝脏生物学的基本进展转化为新的临床治疗方法。这些目标将通过以下方式实现：i）由36位受邀演讲者和多个简短的"最新"演讲，这些演讲将由代表肝脏研究最新进展的初级研究人员提出，以及ii）确保演讲者和会议之间的非正式互动 在整个逗留期间，会议主题包括发育和分化，其中涉及早期肝脏生长的机制，肝脏代谢和外源性物质，肝功能的复杂领域，基因调控，重点是染色质重塑，肝脏生长和 将讨论影响这些过程的疾病状态的再生，肝祖细胞和具有巨大肝脏治疗潜力的令人兴奋的领域，关注可能成为治疗靶点的途径的肝癌发生，肝脏基因治疗和生物工程，其中将介绍肝脏疾病的新方法，肝损伤的机制包括肝脏中各种细胞类型的相互作用以及星状细胞和内皮细胞在该过程中的作用，和病毒性肝炎，其中检查疾病开始和进展的机制。

DESCRIPTION (provided by applicant): The current application seeks partial support for the Federation of American Societies for Experimental Biology (FASEB) summer research conference on "Liver Biology, Development and Disease. For the past 16 years this meeting has been held biannually and is now recognized as the world's premier conference covering all aspects of basic science research involving the liver. The conference will be held from July 22-27, 2006 in Snowmass, Colorado. The main goals of the conference are to i) integrate the research advances offered by disparate areas of liver biology in order to foster new collaborative projects on both a national and international scale, ii) encourage junior investigators and women scientists to pursue liver research to ensure that the study of hepatic disease and biology remains vigorous and iii) accelerate translation of fundamental advances in liver biology into novel clinical treatments through the interaction of basic and clinical researchers. These goals will be achieved through i) the presentations made by thirty-six invited speakers and multiple short 'late-breaking' talks to be presented by junior investigators chosen to represent the most significant recent advances in liver research, and ii) ensuring informal interactions between speakers and conference attendees throughout their stay. Session topics include Development and Differentiation which addresses mechanisms of early liver growth, Liver Metabolism and Xenobiotics, a complex area of liver function, Gene Regulation, with emphasis on new findings in chromatin remodeling, Liver Growth and Regeneration in which disease states that impact these processes will be discussed, Liver Progenitor Cells and exciting area with great potential for liver therapy, Hepatocarcinogenesis which focuses on pathways that may become therapeutic targets, Hepatic Gene Therapy and Bioengineering, in which novel approaches to liver disease will be presented, mechanisms of Liver Injury incorporates the interactions of various cell types in the liver and the role of stellate and endothelial cells in this process, and Viral Hepatitis in which mechanisms of disease initiation and progression are examined.