Conference Proposal: FASEB Nucleic Acid Enzymes

描述(由申请者提供)：题为“核酸酶”的会议将重点讨论由DNA和RNA组成和/或作用于DNA和RNA的酶的结构、机制、生物学作用和医学意义。这次会议吸引了具有结构生物学、生物化学和细胞生物学专业知识的广泛的跨学科科学家小组。这次会议将是美国实验生物学学会联合会(FASEB)在这一领域发起的第六次会议；最近一次是在2004年。会议提供了一个独特的论坛，讨论由核酸组成或作用于核酸的酶，DNA和RNA酶在生物技术中的核心作用，以及与核酸酶有关的代谢紊乱和疾病的日益增多的清单。通过将结构生物学家、生物化学家、细胞生物学家和临床医生聚集在一起讨论共同的兴趣，培养新的见解和跨学科合作。 科学计划将包括以下主题领域的杰出特邀演讲者的八次口头演讲：(1)聚合和保真度；(2)核酸酶；(3)核酸加工和修饰；(4)DNA修复；(5和6)RNA催化剂和剪接I和II；(7)重组和转座；以及(8)RNA形成多肽键。组织者招募了主要的调查人员担任这些会议的讨论负责人。该计划还将包括每日海报会议，从中将挑选来自研究生和博士后与会者的优秀海报进行简短的口头陈述。为了培养一种“新鲜”的方式，以及大量的知识流动和更新，大多数被邀请的演讲者都是新来的，其中相当大一部分是初级教职员工和理科女性，正如提案中所描述的那样。 FASEB 2006会议旨在突出核酸酶学中的几个新兴主题：单分子方法在核酸酶研究中的应用，肽合成和RNA加工之间的相互作用，参与DNA新陈代谢的酶与RNA世界的酶之间的相似性，以及核酸酶对生物技术和医学的迅速影响。会议的亲密形式旨在促进研究RNA和DNA酶不同方面的研究人员之间自由交流信息和思想，从而加快这两个领域的研究。

DESCRIPTION (provided by applicant): The meeting entitled "Nucleic Acid Enzymes" will focus on the structures, mechanisms, biological roles, and medical relevance of enzymes that are composed of, and/or act on DNA and RNA. The meeting attracts a broad cross-disciplinary group of scientists with expertise in structural biology, biochemistry, and cell biology. This meeting will be the 6th sponsored by the Federation of American Societies of Experimental Biology (FASEB) in this area; the most recent was in 2004. The meeting provides a unique forum for the discussion of enzymes that are composed of, or act on nucleic acids, the central role of DNA and RNA enzymology in biotechnology, and the growing list of metabolic disorders and diseases in which nucleic acid enzymes are implicated. By bringing together structural biologists, biochemists, cell biologists and clinicians to discuss common interests, new insights and interdisciplinary collaboration are fostered. The Scientific Program will consist of eight sessions of oral presentations by distinguished invited speakers in the following subject areas: (1) Polymerization and Fidelity; (2) Nucleases; (3) Nucleic acid processing and modification; (4) DNA repair; (5 & 6) RNA catalysts and splicing I and II; (7) Recombination and transposition; and (8) peptide bond formation by RNA. The organizers have recruited leading investigators to serve as discussion leaders for these sessions. The Program will also include daily poster sessions, from which outstanding posters from graduate students and post-doc attendees will be selected for short oral presentations. To foster a 'fresh' approach and significant intellectual turnover and renewal, the majority of invited speakers are new to the meeting, and a significant percentage are junior faculty and women in science, as described in the proposal. The FASEB 2006 meeting aims to highlight several emerging themes in nucleic acids enzymology: the application of single-molecule methods to study of nucleic acid enzymes, the interplay between peptide synthesis and RNA processing, the parallels between enzymes involved in DNA metabolism and those of the RNA world, and the burgeoning impact of nucleic acid enzymes on biotechnology and medicine. The intimate format of the conference is designed to promote free exchange of information and ideas among researchers who work on diverse aspects of RNA and DNA enzymes - thereby expediting research in both fields.