DNA Damage, Mutation and Cancer Gordon Conference

描述(由申请者提供)：申请资助参加第四届和第五届戈登DNA损伤、突变和癌症研究会议的科学家的旅费和/或会议费。第四届会议将于2006年3月5日至9日在美国加利福尼亚州文图拉举行。这次会议以前的标题是突变和癌症发生，在2004年的会议后更名为“DNA损伤、突变和癌症”，以更好地反映我们对处理DNA中各种损伤的关切，以及它们如何引发细胞反应、诱导突变和癌症。在每堂课中，我们将尝试涵盖从化学和结构生物学到生物化学、遗传学和细胞生物学的当前方面。发言者将从DNA加合物及其遗传毒性后果领域的世界专家中挑选出来。这次会议在其他处理基因组不稳定性的GRC会议中是独一无二的，因为它聚集了化学家和生物学家。将作出特别努力，通过在每届会议期间以及在海报展示期间进行公开讨论，优化所有与会者之间的广泛互动，并鼓励少数群体、妇女、研究生和残疾人出席。2006年的会议将包括9场会议，具体如下：(I)自发性损伤：从结构到生物学的最新方面；(Ii)特殊聚合酶如何在病变旁路中发挥作用；(Iii)专业DNA聚合酶和复制DNA聚合酶：它们如何交换位置；(Iv)DNA聚合酶切换的调控：泛素化；(V)通过修复过程/错配修复反应识别损伤；(Vi)大修复/复制复合体的分离和细胞定位；(Vii)通过重组相关机制避免损伤的策略；(Viii)损伤诱导的细胞反应：初始信号的分子性质；(九)DNA损伤在致癌中的作用。

DESCRIPTION (provided by applicant): Funds are requested to support travel and/or conference fees for scientists attending the 4th and 5th biannual Gordon Research Conference on DNA Damage, Mutation and Cancer. The 4th conference will be held March 5-9, 2006 in Ventura, CA (USA). This conference, previously entitled Mutagenesis and Carcinogenesis, was renamed "DNA Damage, Mutation and Cancer" following the 2004 meeting to better reflect our concerns to deal with the large diversity of lesions in DNA, how they elicit cellular responses, induce mutations and cancer. In each session, we will try to cover current aspects ranging from chemistry and structural biology, to biochemistry, genetics and cellular biology. Speakers will be selected from among the world experts in the field of DNA adducts and their genotoxic consequences. This meeting is unique among the other GRC conferences that deal with genome instability as it brings together chemists and biologists. Special efforts will be made to optimize extensive interactions among all attendees through open discussions within each session as well as during the poster presentations and to encourage the attendance of minority groups, women, graduate students and persons with disabilities. The 2006 meeting will include nine sessions as specified below: (i) Spontaneous lesions: recent aspects ranging from structure to biology; (ii) How the specialized polymerases function in lesion bypass ; (iii) Specialized DNA polymerases and replicative DNA polymerases: how they trade places; (iv) Regulation of DNA Polymerases switching: ubiquitination; (v) Lesion recognition by repair processes / Mismatch repair responses to DNA lesions; (vi) Isolation and cellular localization of large repair / replication complexes; (vii) Damage avoidance strategies by recombination related mechanisms; (viii) Damage induced cellular responses: the molecular nature of the initial signals; (ix) The role of DNA damage in the induction of cancer.