Malaria: Functional Genomics to Biology to Medicine

关于疟原虫的基本生物学知识在过去十年中突飞猛进。现在已经完成了基因组序列，有了对寄生虫进行分子遗传操作的方法，正在收集基因表达和蛋白质表达的详细描述，对寄生虫基本生物学的研究大大加强了我们对这种有机体的了解。然而，疟疾仍然是一个主要的世界卫生问题，每年有超过5亿人受到感染，有100万至300万人死亡，主要是非洲儿童。本次会议将侧重于寄生虫系统生物学的详细研究，包括种群生物学和遗传多样性、宿主寄生虫和寄生虫媒介的相互作用、

Knowledge in the basic biology of the malaria parasite has exploded over the past ten years. The genome sequence is now completed, methods for molecular genetic manipulation of the parasite are available, detailed descriptions of gene expression and protein expression are being assembled, and studies on the basic biology of the parasite have greatly enhanced our understanding of the organism yet, malaria remains a major world health problem with over 500 million people infected each year and one to three million deaths, primarily in children in Africa. This meeting will focus on a detailed examination of parasite systems biology, including population biology and genetic diversity, host parasite and parasite vector interactions, including immunology with to goal of identifying new insights for future intervention. It will bring together experts in parasite biology with experts in related disciplines with the hopes of developing new paradigms for drug and vaccine development.