ANIMAL HEALTH RESOURCES IMPROVEMENT PROJECT

描述（由申请人提供）：弗雷德哈钦森癌症研究中心（FHCRC）汇集了200多名在基础、临床和公共卫生科学方面有研究兴趣的FHCRC教师。为了保持与同行机构的竞争力，FHCRC必须能够适应动物卫生资源（AHR）空间对新教师和现有项目增长的需求。目前有79名研究人员在FHCRC南湖联盟利用动物在大约200个活跃的和批准的IACUC协议在现有设施内进行他们的研究项目。在过去的4个财政年度里，AHR部门的护理日增加了大约69%，其中大部分的增加主要是由于在现有教员中扩大了转基因啮齿动物的使用。增加新的教员到FHCRC和扩大现有研究人员的需求预计将有助于这一趋势的延续。FHCRC目前正在为其啮齿动物群落完成向单独通风和HEPA过滤笼的初步过渡，这将允许在现有设施空间内增加其动物种群的住房密度。目前有必要满足不断增长的需求，通风机架容量的持续安装和扩展。所需经费用于购买17个双面和19个单面通风机架系统及相关配件。所要求的额外机架将使我们能够在现有设施内最大限度地提高动物住房密度，为所有依赖小鼠模型进行癌症相关研究项目的中心教师提供好处。有全面和互补的动物设施使用程序，并结合通风笼，解决所有使用区域的人员和物质流动问题，以排除可能危及动物健康和科学质量的啮齿动物病原体。

DESCRIPTION (provided by applicant):The Fred Hutchinson Cancer Research Center (FHCRC) brings together more than 200 FHCRC faculty with research interests in basic, clinical and public health sciences. To remain competitive with peer institutions, the FHCRC must be capable of accommodating the Animal Health Resource (AHR) space needs for new faculty and growth in the existing programs. There are presently 79 investigators on the FHCRC South Lake Union utilizing animals in approximately 200 active and approved IACUC protocols for their programs of study within the existing facilities. The AHR department has experienced an approximate 69% increase in care days over the past 4 fiscal years, with most of the increase principally due to expanding use of genetically modified rodents among existing faculty. Addition of new faculty to the FHCRC and expanding needs of current investigators are expected to contribute to a continuation of this trend. The FHCRC is currently completing an initial transition to individually ventilated and HEPA filtered caging for its rodent colonies, which will allow increased housing density within existing facility space for its animal populations. Currently there is a need to meet the growing demand, with continued installation and expansion of ventilated rack capacity. Funding is requested for the purchase of 17 double faced and 19 single faced ventilated rack systems with associated accessories. The additional racks requested will allow us to maximize animal housing densities within the existing facility, providing benefit to all Center faculty who rely upon mouse models for their cancer related research projects. There are comprehensive and complementary animal facility use procedures in conjunction with the ventilated caging that address personnel and material flow in all areas of use to provide for exclusion of rodent pathogens which could jeopardize animal health and scientific quality.