Imaging and the Aging Brain

描述(申请人提供)：纽约科学院和美国老龄化研究联合会计划于2006年5月16日和17日在纽约市举行为期两天的会议，题为/成像和老龄化大脑。65岁或以上的美国老年人口目前超过3590万，预计到2030年将达到7150万，使这一部分人口占美国总人口的20%。这些人口统计数据表明，越来越需要对与衰老过程有关的疾病进行更深入的研究，并更好地了解标准的衰老过程。与年龄相关的变化发生在大脑功能和解剖学上。其中一些变化是正常衰老过程的一部分，而其他变化与病理变化有关，最终导致阿尔茨海默病(AD)、帕金森病(PD)、中风、痴呆症和轻度认知障碍(MCI)等疾病。重要的相关问题是在分子、细胞和系统层面上发生了什么？而且，与疾病相关的调节相比，这在标准衰老方面有什么不同？这次会议将汇集成像科学家、研究衰老大脑的人、工业专家和临床医生，共同探索最新的方法及其在脑生理学、行为和年龄相关疾病中的应用。神经成像的进展为年龄相关疾病的病因学提供了新的见解，也为观察正常衰老对大脑的影响提供了机会。这次研讨会预计将聚集多达200名科学界领袖，探索新技术、来自最近的神经成像倡议的数据和翻译研究应用。为期两天的会议将交织脑和神经成像的多种模式，以及分子、细胞、系统、动物模型和人类受试者和患者的渐进进化。这次会议分为4个主题，涵盖衰老和脑成像交叉的关键领域：1.分子的活体成像；2.整个生命周期中的细胞和网络；3.衰老的成像和生理学；4.翻译应用；5.成像的前沿技术。

DESCRIPTION (provided by applicant): The New York Academy of Sciences with the American Federation of Aging Research is planning a 2-day conference entitled/Imaging and the Aging Brain" to be held May 16th and 17th, 2006 in New York City. The number of older Americans, age 65 or greater is currently over 35.9 million, and is expected to reach 71.5 million by 2030, making this segment of the US population 20% of the total. These demographics bring to light the increased need for more intensive studies of diseases related to the aging process as well as a better understanding of the normative aging process. Age-related changes occur in brain function and anatomy. Some of these alterations are part of the normal aging process while other changes are associated with pathologic changes, ultimately resulting in diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), stroke, dementia, and mild cognitive impairment (MCI). Important related questions are what occur at the molecular, cellular and system wide levels? And, how does this differ in normative aging as compared with disease-associated modulation? The meeting will bring together imaging scientists, those studying the aging brain, industrial experts and clinicians to jointly explore the most current methodologies and their application to brain physiology, behavior and age-related diseases. Advances in neuroimaging are providing new insights into the etiology of age-related diseases, as well as an opportunity to view the effects of normative aging on the brain. This symposium is expected to bring together as many as 200 leaders in the scientific community to explore new technologies, data from recent neuroimaging initiatives and translational research applications. The 2-day meeting will interleave the multiple modalities of brain and neuroimaging along with a progressive evolution from molecules, cells, systems, animal models and human subjects and patients. The conference is organized into 4 main themes encompassing key areas at the intersection of aging and brain imaging:1. In vivo imaging of molecules,2. Cells and networks throughout the lifespan;3. Imaging and physiology of aging; 4. Translational applications; 5. and Technologies at the forefront of imaging.