Developing new metal-based complexes for 18F-based radiopharmaceutical (PET) imaging applications

该项目专注于通过正电子发射断层扫描(PET)开发用于放射性氟化的新金属络合物，作为下一代医学显像剂的潜在应用-正电子发射断层扫描(PET)是一种非常广泛使用的医疗成像技术，用于检测癌症等疾病。该项目处于合成化学/放射化学界面，成功的申请者将有机会开发具有大环共配体的金属氟化物络合物作为可能的PET示踪剂候选，以及利用圣托马斯医院(伦敦)的GE设施开发有效的方法进行其放射性氟化(使用氟-18同位素)、纯化和稳定性测试。

The project focusses on development of new metal complexes for radiofluorination for potential applications as next generation medical imaging agents via positron emission tomography (PET) - a very widely used medical imaging technique used in hospitals and clinics for detection of diseases such as cancers.This project is at the synthetic chemistry/radiochemistry interface and the successful applicant will have the opportunity to develop metal fluoride complexes with macrocyclic co-ligands as possible PET tracer candidates, as well as to use the GE facilities at St Thomas' Hospital (London) to develop efficient methods for their radiofluorination (using the fluorine-18 isotope), purification and stability testing.