Data Coordinating Center for Sleep Heart Health

描述（由申请人提供）：本申请提出了一项计划，旨在继续在约翰霍普金斯大学彭博公共卫生学院临床试验中心和流行病学和生物统计学部门内开展睡眠心脏健康研究协调中心（CC）。SHHS始于1994年，是一项多中心前瞻性队列研究，旨在研究睡眠呼吸障碍（SDB）对心血管的影响。从各种正在进行的研究中抽取了6441人，并进行了夜间在家多导睡眠图（PSG）；3295名参与者在5年后进行了第二次PSG。正在申请资金继续跟踪SHHS队列的伴随申请：“睡眠心脏健康研究（SHHS）”。在SHHS的最初五年里，中心设在华盛顿大学公共卫生学院，随后的五年资金转移到约翰霍普金斯大学。在约翰霍普金斯大学CC运作的头四年里，SHHS数据库被转移到CCT，一个数据系统和表格被建立起来，以支持第二波多波睡眠图（psg），进行数据分析，并维持其他管理功能，包括委员会运作。在此申请的四年资助期内，SHHS的重点将是完成队列的随访，并开展分析，以解决研究中与睡眠呼吸障碍（SDB）和心血管疾病风险相关的原始假设，包括高血压、急性心血管事件和中风。

DESCRIPTION (provided by applicant): This application presents a plan for continuing the Coordinating Center (CC) for the Sleep Heart Health Study (SHHS) within the Center for Clinical Trials and Departments of Epidemiology and Biostatistics of the Johns Hopkins Bloomberg School of Public Health. The SHHS was started in 1994 as a multicenter prospective cohort study of the cardiovascular consequences of sleep-disordered breathing (SDB). A cohort of 6441 persons, drawn from various ongoing studies was enrolled and had an overnight in-home polysomnogram (PSG); 3295 participants had a second PSG 5 years later. Funds are being requested to continue follow-up of the SHHS cohort in a companion application: "The Sleep Heart Health Study (SHHS)." The CC was housed at the University of Washington School of Public Health for the initial five years of the SHHS and was then transferred to Johns Hopkins for the subsequent five years of funding. During the first four years of CC operations at Johns Hopkins, the SHHS data base was migrated to the CCT, a data system and forms were put in place in support of the second wave of polysomnograms (PSGs), data analysis was carried out, and other administration functions were maintained, including committee operations. During the four years of funding requested with this application, the focus of the SHHS will be on completing follow-up of the cohort and carrying out analyses to address the study's original hypotheses related to sleep-disordered breathing (SDB) and risk for cardiovascular disease, including hypertension and acute cardiovascular events and stroke. Accordingly, during the requested four years of support, the CC will carry out the following functions: 1) continue to maintain the SHHS data base, adding follow-up information as it is developed by the SHHS field sites and the Adjudication Committee; 2) provide central analyses of the SHHS data, particularly for the longitudinal analyses focusing on the study's primary hypotheses; 3) coordinate operations of the SHHS committees including the Steering Committee and its subcommittees, the Presentation and Publications Subcommittee, and the Morbidity and Mortality Subcommittee; 4) maintain the SHHS website and respond to requests for data access and sharing; 5) schedule and staff the required annual Observational Safety and Monitoring Board (OSMB) meetings; and 6) coordinate the closing down of the study at the end of the SHHS.