Gated Optical Detectors/Dose Guided Radiotherapy

与海军研究实验室合作开发的光辐射探测器已经形成了一种探测系统，该系统采用加速器枪触发脉冲作为数据采集的电子门，从而消除了由于切伦科夫辐射而产生的场和剂量率相关的污染物。由此产生的检测器体积小，灵敏度高，具有线性响应和宽动态范围。已经进行了体模研究，正在进行有限的临床部署。初始阶段是研究少量离散光纤在剂量验证中的临床实用性。下一步是将纤维阵列开发为矩形或螺旋网格，并研究放射治疗期间产生的剂量图以及器官或射束定位的微小变化的影响。第三阶段是理解相对于患者解剖位置的信号变化的含义，并且如果检测到的信号与参考值相差预定的容限，则中断治疗。第四和最后阶段是将网格信号的变化动态地链接到辐射场中的校正变化，用于辐射治疗的在线、动态剂量控制。

The development of optical radiation detectors in conjunction with the Naval Research Laboratories has resulted in a detection system that employes the accelerator gun trigger pulses as an electronic gate for data acquisition; thereby eliminating the field and dose rate dependent contaminant due to Cerenkov radiation. The resulting detector is small and very sensitive, with a linear response and a wide dynamic range. Phantom studies have been performed and limited clinical deployment is underway. The initial phase is to stude the clinical utility of a small number of discrete fibers in dose verification. The next step is to develop an array of fibers as either a rectangular or spiral grid and study the dose map generated during radiotherapy and the effect of small changes in organ or beam positioning. The third phase is to understand the meaning of signal change relative to the patient's anatomical position and to interrupt the treatment if detected signals differ from reference values by a predetermined tolerance margin. The fourth and final phase is to dynamically link the changes in grid signals to corrective changes in the radiation field for on-line, dynamic dose control of radiation treatments.