Effect Of Epinephrine In A Canine Model Of Septic Shock

在脓毒症发展的早期，心肺和外周联合作用导致血压降低，外周维持血压的能力降低，从心脏泵出的血液正常到增加。在死亡患者中，终末期感染性休克的特征是低血压和心脏泵出血液的能力降低，导致多器官系统衰竭和死亡。无法解决心脏功能障碍和维持足够的血液流向器官是导致患者死亡的最重要因素。脓毒症患者的治疗包括给予液体和血管增压剂以维持血压，同时给予抗生素以杀死细菌。目前，败血症的犬模型使用细菌凝块，并使用液体和抗生素进行治疗。这项研究的目的是确定在脓毒症期间维持血压的肾上腺素剂量所需的动物数量，以及这是否会对预后产生有益的影响。肾上腺素的使用应该使我们能够更准确地描述人类脓毒症的治疗，并解决低血压和心输出量的问题。

Early in the development of sepsis, the combined cardiopulmonary and peripheral effects result in a decreased blood pressure, reduced ability to maintain blood pressure in the periphery and normal to increased blood pumped out of the heart. In non-survivors, end-stage septic shock is characterized by a low blood pressure and a reduced ability to pump blood out of the heart resulting in multiple organ system failure and death. The inability to resolve the heart dysfunction and maintain adequate blood flow to the organs is the most significant contributing factor to the demise of the patient. Treatment of patients with sepsis consists of giving fluids and vasopressors to maintain blood pressure while giving antibiotics to kill the bacteria. At present, the canine model of sepsis uses a bacterial clot and is treated with fluids and antibiotics. The purpose of this study is to determine the number of animals necessary to determine the dose of epinephrine that will maintain blood pressure during sepsis and if this will have a beneficial effect on outcome. The use of epinephrine should allow us to more accurately characterize the treatment of sepsis in humans and address the low blood pressure and cardiac output.