Understanding glial cell sensing and shape changing feedback during morphogenesis by integrating simulations and in vivo zebrafish experiments

发育形态发生中的细胞需要来自环境的反馈，以找到正确的位置并建立功能形状。在体内理解这些过程具有挑战性，因此该项目将整合模拟，以提供必要的解释力来解开复杂的反馈。Bentley实验室是开发预测细胞模拟的专家，MacDonald实验室是了解神经系统支持细胞胶质细胞的活体专家。为了对神经元进行许多支持性功能，神经胶质细胞必须在突触连接中正确定位，但神经胶质细胞如何实现这一点仍有待探索。

Cells in developmental morphogenesis require feedback from their environment to findtheir correct positions and establish functional shapes. The processes are challengingto understand in vivo so this project will integrate simulations to provide essentialexplanatory power to untangle the complex feedback. The Bentley laboratory areexpert in developing predictive cell simulations and the MacDonald lab are in vivoexperts understanding glial cells, the support cells of the nervous system. In order toconduct their many supportive functions for neurons, glial cells must be positionedcorrectly amongst the synaptic connections, but how glial cells achieve this remains tobe explored.