DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

描述（由申请人提供）： 维克森林大学医学院（WFUSM）计划其研究项目的未来增长。为了支持这一增长，该机构四个校区中的两个已经在进行或计划建造新的动物住房空间。未来几年，建设新的研究空间将需要大量的机构投资。在与华盛顿国家灵长类动物研究中心（WaNPRC）合作，我们建议利用WFUSM可用的繁殖空间，从WaNPRC的房子繁殖殖民地生产特定病原体免费（SPF）的婴儿，以支持生物医学界的研究需求。WaNPRC正在提交一份题为“WaNPRC-WFUSM食蟹猴SPF育种群”的并行P40申请。由于已知NHP短缺，这些申请如果得到资助，将解决SPF猴子研究对象的严重短缺问题。该提案要求资金用于：1）修改现有的畜舍，以提供更多可用的群体繁殖畜舍，2）提供更好的婴儿护理设备。该G20应用程序和WaNPRC的P40应用程序代表了具有成本效益和独特资格的合作伙伴关系，以满足预计将持续到未来的国家需求。仅在美国医学会联合会，这些改进将直接影响39名调查员的研究，他们目前在外部资助的项目中持有1 220万美元（年度直接费用），17名调查员申请了740万美元（年度直接费用）的待决项目。如果获得资助，该申请将为WaNPRC和WFUSM提供一种机制，以经济有效地利用现有资源，利用每个小组在非人灵长类动物繁殖和群体管理方面的互补专业知识，并准备帮助支持新的国家倡议和已经成功的研究计划。

DESCRIPTION (provided by applicant): The Wake Forest University School of Medicine (WFUSM) projects future growth of its research programs. To support this growth, construction of new animal housing space is already underway or planned on two of the institution's four campuses. Construction of new research space will require considerable institutional investment over the next few years. In collaboration with the Washington National Primate Research Center (WaNPRC), we propose to utilize WFUSM available breeding space to house breeding colonies from WaNPRC to produce specific pathogen free (SPF) infants to support research needs for the biomedical community. A concurrent P40 application is being submitted by WaNPRC, entitled "WaNPRC-WFUSM Macaca fascicularis SPF Breeding Colony". As there is a known shortage of NHP, these applications, if funded, would address a critical shortage of need for SPF monkey research subjects. This proposal requests funds to: 1) modify existing corrals to provide more usable group harem breeding corrals, and 2) provide equipment for better infant care. This G20 application and the P40 application from WaNPRC represent a cost-effective and uniquely qualified partnership to address a national need that is projected to continue well into the future. At WFUSM alone, these improvements will directly impact the research of 39 investigators who currently hold $12.2 million (annual direct costs) in externally funded projects, and 17 investigators who have applied for $7.4 million (annual direct costs) in pending projects. If funded, this application will provide a mechanism for WaNPRC and WFUSM to cost-effectively use existing resources, take advantage of each group's complementary expertise in nonhuman primate breeding and colony management, and be poised to help support new national initiatives and already successful research programs.