Developing a Novel Multimodal Training System toAaid Effective Recovery from Impairment of Smell, Taste and Chemesthesis

味觉的丧失对生活质量有很大的影响，因为它可能导致体重减轻、营养不良和抑郁。受影响的两个主要群体是：(1)到2050年将达到21亿的老年人；ii)全球5060万COVID-19康复患者中，76%和89%报告味觉和嗅觉丧失，46%报告化学反应减少。嗅觉训练（每天嗅两次精油，持续4个月）在一些研究中证明了它对知觉恢复的好处，因为它刺激嗅觉细胞，有助于加强大脑中的神经通路。本研究的目的是为基于口香糖系统的多模态（即嗅觉、味觉和三叉神经感觉的组合）训练工具的设计提供基础和应用知识，以帮助感知丧失的人类有效恢复。

The loss of flavour perception has a strong impact on the quality of life as it may lead to weight loss, malnutrition, and depression. Two main affected groups are i) older adults of 2.1 billion by 2050; ii) COVID-19 recovery patients of 50.6 million globally with 76% and 89% reported the loss of taste and smell plus 46% had a reduction of chemethesis. Olfactory training (sniffing essential oils twice daily for 4-month) demonstrated its benefit on the recovery of perception in some studies because it stimulates the olfactory cells and helps to strengthen the neural pathway in the brain. The aim of this study is to generate fundamental and applied knowledge on the design of a multimodal (i.e., combination of olfaction, gustation, and trigeminal sensation) training tool based on the chewing gum system to aid effective recovery for humans with loss of perception.