Effect of Exercise on Prevention of Weight Gain

据估计，美国超过50%的成年人超重（体重指数为25kg /m2）。特别值得关注的是，在过去的几十年里，肥胖患病率的显著增加（体重指数bbb30 kg/ m2）。锻炼似乎是预防和治疗许多慢性疾病的重要行为，目前公共卫生建议的锻炼是每周大部分时间进行30分钟中等强度的活动（每周总共150分钟）。然而，目前尚不清楚这种水平的运动是否足以防止体重增加和肥胖的发展。因此，本研究的目的是检验两种剂量的运动对预防中度超重成年人体重增加的影响。本次研究将招募294名受试者。受试者年龄为18-50岁，体重指数为25.0 - 29.9 kg/ m2。受试者将被招募为三个队列，每个队列有98名受试者。受试者将被随机分配到以下三个治疗组之一：1)控制，2)适度运动，或3)高强度运动。所有受试者将被随访18个月。对照组将每3个月收到一份简讯中的基本健康信息。中度运动组的受试者将进行至少150分钟的中等强度运动。高强度运动组的受试者将进行至少300分钟的中等强度运动。中度运动组和高强度运动组的受试者在6个月内每周参加一次行为会议，之后每两周参加一次，每月进行一次电话联系。本研究的主要结果将是体重从基线到18个月的变化。此外，受试者将在0和18个月时接受身体成分（使用DEXA）和心肺健康评估。在整个研究过程中，我们还将每隔3个月评估一次身体活动、饮食和行为变化的潜在媒介的变化。这项研究的结果将对预防成年人体重增加的运动建议产生重大影响。网站性能 ======================================== 节结束 ===========================================

EXCEED THE SPACE PROVIDED, It is estimated that in excess of 50 percent of adults in the United States are overweight (body mass index >25 kg/m2). Of particular concern is the significant increase in the prevalence of obesity (body mass index >30 kg/m 2) over the past few decades. Exercise appears to be an important behavior for preventing a treating a number of chronic diseases, and the current public health recommendation for exercise is 30 minutes of moderate intensity activity on most days of the week (150 minutes per week total). However, it is unclear whether this level of exercise is adequate for preventing weight gain and the development of obesity. Therefore, the purpose of this study is to examine the effect of two doses of exercise on prevention of weight gain in moderately overweight adults. Two-hundred ninety four (294) subjects will be recruited to participate in this study. Subjects will be 18-50 years of age, with a body mass index ranging from 25.0 to 29.9 kg/m 2. Subjects will be recruited in three cohorts, with 98 subjects per cohort. Subjects will be randomly assigned to one of the following three treatment groups: 1) control, 2) moderate exercise, or 3) high exercise. All subjects will be followed for a period of 18 months. The control group will receive basic health information in a newsletter at 3 month intervals. Subjects in the moderate exercise group will progress to 150 minutes of at least moderate intensity exercise. Subjects in the high exercise group will progress to approximately 300 minutes of at least moderate intensity exercise. Subjects in both the moderate and high exercise groups will attend weekly behavioral sessions weekly for 6 months, and biweekly thereafter along with 1 telephone contact per month. The primary outcome of this study will be change in body weight from baseline to 18 months. In addition, subjects will undergo assessment of body composition (using DEXA) and cardiorespiratory fitness at 0 and 18 months. We will also assess changes in physical activity, diet, and potential mediators of change in behaviors at 3-month intervals throughout this study. This results of this study will have a significant impact on exercise recommendations for preventing weight gain in adults. PERFORMANCE SITE ========================================Section End===========================================